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ATG16L1 / ATG16L

autophagy related 16-like 1 (S. cerevisiae)

Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.

Gene Name: autophagy related 16-like 1 (S. cerevisiae)
Synonyms: ATG16L1, APG16-like 1, APG16L, APG16L beta, ATG16L, Autophagy-related protein 16-1, IBD10, WD repeat domain 30, ATG16A, WDR30
Target Sequences: NM_017974 NP_060444.3 Q676U5

Publications (7)

1
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Plantinga TS, Crisan TO, Oosting M, van de Veerdonk FL, de Jong DJ, Philpott DJ, van der Meer JW, Girardin SE, Joosten LA, Netea MG. Gut. 2011 60:1229-35. [PubMed:21406388]
2
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado-Joseph disease. Nascimento-Ferreira I, Santos-Ferreira T, Sousa-Ferreira L, Auregan G, Onofre I, Alves S, Dufour N, Colomer Gould VF, Koeppen A, Dglon N, Pereira de Almeida L. Brain : a journal of neurology. 2011 134:1400-15. [PubMed:21478185] Related Antibodies: LS-C156571.
3
NOD2 enhances the innate response of alveolar macrophages to Mycobacterium tuberculosis in humans. Jurez E, Carranza C, Hernndez-Snchez F, Len-Contreras JC, Hernndez-Pando R, Escobedo D, Torres M, Sada E. European journal of immunology. 2012 42:880-9. (Human) [PubMed:22531915]
4
Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program. Tattoli I, Sorbara MT, Vuckovic D, Ling A, Soares F, Carneiro LA, Yang C, Emili A, Philpott DJ, Girardin SE. Cell host & microbe. 2012 11:563-75. (WB; Human) [PubMed:22704617]
5
Identification of autophagic vacuoles and regulators of autophagy in villous trophoblast from normal term pregnancies and in fetal growth restriction. Curtis S, Jones CJ, Garrod A, Hulme CH, Heazell AE. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2013 26:339-46. (IHC; Human) [PubMed:23039021]
6
Downregulation of Autophagy-Related Proteins 1, 5, and 16 in Testicular Germ Cell Tumors Parallels Lowered LC3B and Elevated p62 Levels, Suggesting Reduced Basal Autophagy. Liu H, He Z, Bode P, Moch H, Simon HU. Frontiers in oncology. 2018 September;8:366. [Full Text Article] [PubMed:30245976] [PMC:PMC6137693] Related Antibodies: LS-B2723.
7
Machine learning with autophagy-related proteins for discriminating renal cell carcinoma subtypes. Zhaoyue He, He Liu, Holger Moch, Hans-Uwe Simon. Scientific reports. 2020 Jan;10:720. [Full Text Article] [PubMed:31959887] [PMC:PMC6971298] Related Antibodies: LS-B2723.
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Proteins (10)
Over-Expression Lysate (4)
Recombinant (6)
ATG16L1 / ATG16L (10)
No (10)
GST (1)
GST, N-terminus (1)
His (1)
His-GST-S (1)
His-SUMO (1)
His-T7 (1)
Myc-DDK (Flag) (4)
Human (8)
293T Cells (2)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (2)
Yeast (1)
Purified (1)
ATG16L1 / ATG16L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human ATG16L1 / ATG16L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90752
293T Cells
Myc-DDK (Flag)
58.7 kDa
20 µg/$150
ATG16L1 / ATG16L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
Human ATG16L1 / ATG16L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90753
293T Cells
Myc-DDK (Flag)
68.1 kDa
20 µg/$215
ATG16L1 / ATG16L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
ATG16L1 / ATG16L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109391
HEK 293 Cells
Myc-DDK (Flag)
68.1 kDa
100 µg/$710
ATG16L1 / ATG16L Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
ATG16L1 / ATG16L Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G131014
HEK 293 Cells
Myc-DDK (Flag)
58.7 kDa
100 µg/$494
ATG16L1 / ATG16L Protein
Select
Human ATG16L1 / ATG16L Protein (Recombinant His-SUMO) (Full Length) - LS-G21745
E. coli
His-SUMO
84.22 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
ATG16L1 / ATG16L Protein
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Human ATG16L1 / ATG16L Protein (Recombinant His) (Full Length) - LS-G23415
Yeast
His
70.27 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
ATG16L1 / ATG16L Protein - Recombinant Autophagy Related Protein 16 Like Protein 1 By SDS-PAGE
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Human ATG16L1 / ATG16L Protein (Recombinant His-GST-S) (aa1-284) - LS-G26213
E. coli
His-GST-S
62.8 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ATG16L1 / ATG16L Protein - Recombinant Autophagy Related Protein 16 Like Protein 1 By SDS-PAGE
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Human ATG16L1 / ATG16L Protein (Recombinant His-T7) (aa342-607) - LS-G26214
E. coli
His-T7
33.1 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ATG16L1 / ATG16L Protein - 12.5% SDS-PAGE of human ATG16L1 stained with Coomassie Blue
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Human ATG16L1 / ATG16L Protein (Recombinant GST) (Full Length) - LS-G34163
Wheat Germ Extract
GST
84.7 kDa
2 µg/$439
ATG16L1 / ATG16L Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Human ATG16L1 / ATG16L Protein (Recombinant GST, N-terminus) (aa459-541) - LS-G62648
Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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