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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ATF2

activating transcription factor 2

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

Gene Name: activating transcription factor 2
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: ATF2, CREB-2, CRE-BP1, CREB2, HB16, TREB7, CREBP1
Target Sequences: NM_001880 NP_001871.2 P15336

Publications (1)

1
Dephosphorylation of beta-arrestin 1 in glioblastomas. Mandell JW, Glass G, Gianchandani EP, Locke CN, Amos S, Bourne TD, Schiff D, Papin JA. Journal of neuropathology and experimental neurology. 2009 68:535-41. (IHC, WB) [PubMed:19404096]

Filtered by: None
Type
Over-Expression Lysate (2)
Recombinant (5)
Target
ATF2 (7)
Tag
GST (1)
GST,N-terminus (2)
His + GST (1)
His + SUMO (1)
Myc + DDK (2)
Species
Human (6)
Source
293T Cells (1)
Baculovirus (1)
E. coli (1)
HEK 293 Cells (1)
Wheat Germ Extract (3)
Purification
Purified (2)
Low Endotoxin Level
Low endotoxin level (1)
Publications
No (7)
Showing 1-7 of 7 results

Human ATF2 Protein (Recombinant His + SUMO) (Full Length) - LS-G20506
E. coli
His + SUMO
70.5 kD
1000µg  $1,245.00; 500µg  $785.00; 200µg  $475.00; 50µg 0.1mg/ml  $275.00; 10µg  $235.00; 100µg  $355.00
Sodium Dodecyl Sulfate - Polyacrylamide Gel Electrophoresis Image

Human ATF2 Protein (Recombinant GST,N-terminus) (aa91-190) - LS-G58207
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human ATF2 Protein (Recombinant GST,N-terminus) (aa137-236) - LS-G58206
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human ATF2 Protein (Recombinant GST) (Full Length) - LS-G28016
Wheat Germ Extract
GST
48.73 kDa
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE of human ATF2 stained with Coomassie Blue

Human ATF2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G88045
293T Cells
Myc + DDK
54.4 kDa
20µg  $195.00

ATF2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G99586
HEK 293 Cells
Myc + DDK
54.4 kDa
100µg  $475.00

Human ATF2 Protein (Recombinant His + GST) (Met1-Ser505) - LS-G97169
Baculovirus
His + GST
Less than 1.0 EU/µg protein (determined by LAL method).
82.4 kDa
50µg  $445.00; 100µg  $680.00
Showing 1-7 of 7 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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