ATF2

activating transcription factor 2

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

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Products

Proteins (7)

Type

Recombinant (7)

Target

ATF2 (7)

Publications

No (7)

Tag

GST (1)

GST, N-terminus (2)

His, N-Terminal (1)

His,C-terminus (1)

His-GST (1)

His-SUMO (1)

Species

Human (7)

Source

Baculovirus (1)

E. coli (2)

Sf9 Cells (1)

Wheat Germ Extract (3)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human ATF2 Protein (Recombinant His-SUMO) (Full Length) - LS-G20506

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

70.5 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ATF2 Protein (Recombinant GST) (Full Length) - LS-G28016

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.73 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ATF2 Protein (Recombinant His,C-terminus) - LS-G142322

Source:

Sf9 Cells

Tag:

His,C-terminus

Molecular Weight:

55 kDa

Price:

20 µg/$677

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Human ATF2 Protein (Recombinant His, N-Terminal) - LS-G144222

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

54.4 kDa

Price:

50 µg/$419

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Human ATF2 Protein (Recombinant GST, N-terminus) (aa137-236) - LS-G58206

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ATF2 Protein (Recombinant GST, N-terminus) (aa91-190) - LS-G58207

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ATF2 Protein (Recombinant His-GST) (Met1-Ser505) - LS-G97169

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

82.4 kDa

Price:

100 µg/$1,047

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