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ATF2

activating transcription factor 2

Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). Exhibits histone acetyltransferase (HAT) activity which specifically acetylates histones H2B and H4 in vitro. In concert with CUL3 and RBX1, promotes the degradation of KAT5 thereby attenuating its ability to acetylate and activate ATM. Can elicit oncogenic or tumor suppressor activities depending on the tissue or cell type.

Gene Name: activating transcription factor 2
Family/Subfamily: Transcription factor , not assigned-Transcription factor
Synonyms: ATF2, CREB-2, CRE-BP1, CREB2, HB16, TREB7, CREBP1
Target Sequences: NM_001880 NP_001871.2 P15336

Publications (1)

1
Dephosphorylation of beta-arrestin 1 in glioblastomas. Mandell JW, Glass G, Gianchandani EP, Locke CN, Amos S, Bourne TD, Schiff D, Papin JA. Journal of neuropathology and experimental neurology. 2009 68:535-41. (IHC, WB) [PubMed:19404096]

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ELISA Kits (18)
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ATF2 (18)
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Mouse (11)
Rat (13)
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12 x 8-Well Microstrips (4)
96-Well Microplate (8)
96-Well Strip Plate (6)
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Adherent Cell Cultures (7)
Cell Lysates (4)
Nuclear Lysates (4)
Plasma (4)
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Tissue Homogenates (2)
ATF2 ELISA Kit
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Cell-Based Phosphorylation
96-Well Microplate
Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ATF2 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$534
ATF2 ELISA Kit
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DNA Binding
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$662
ATF2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ATF2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ATF2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ATF2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ATF2 ELISA Kit
Select
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
ATF2 ELISA Kit
Select
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
ATF2 ELISA Kit
Select
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
ATF2 ELISA Kit
Select
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
ATF2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$669
ATF2 ELISA Kit
Select
Custom
96-Well Strip Plate
Chicken
Colorimetric - 450nm (TMB)
1 Plate/$783
ATF2 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$669
ATF2 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$669
ATF2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ATF2 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$586
ATF2 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
15.625 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).