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ASPIC1 / CRTAC1
cartilage acidic protein 1
ASPIC1 / CRTAC1 encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants.
| Gene Name: | cartilage acidic protein 1 |
| Synonyms: | CRTAC1, ASPIC1, ASPIC, CEP-68, Cartilage acidic protein 1 |
| Target Sequences: | NM_018058 NP_060528.3 Q9NQ79 |
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