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ASGR2

asialoglycoprotein receptor 2

ASGR2 is a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Name: asialoglycoprotein receptor 2
Synonyms: ASGR2, ASGPR2, Asialoglycoprotein receptors 2, ASGP-R 2, ASGPR 2, ASGP-R2, Asialoglycoprotein receptor 2, CLEC4H2, Hepatic lectin H2, HL-2, HBxAg-binding protein, HBXBP
Target Sequences: NM_001181 NP_001172.1 P07307

Publications (1)

1
Pattern-Specific Transcriptomics Identifies ASGR2 as a Predictor of Hematogenous Recurrence of Gastric Cancer. Tanaka H, Kanda M, Miwa T, Tanaka C, Kobayashi D, Umeda S, Shibata M, Suenaga M, Hattori N, Hayashi M, Iwata N, Yamada S, Nakayama G, Fujiwara M, Kodera Y. Molecular cancer research : MCR. 2018 September;16:1420-1429. [Full Text Article] [PubMed:29784667] Related Antibodies: LS-C196698.

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Products
Proteins (15)
Over-Expression Lysate (8)
Recombinant (7)
ASGR2 (15)
No (15)
10His, N-terminus + Myc, C-terminus (1)
10His-SUMO, N-terminus + Myc, C-terminus (1)
GST (1)
His (1)
His-T7 (1)
Myc-DDK (Flag) (10)
Human (9)
Mouse (2)
293T Cells (4)
E. coli (4)
HEK 293 Cells (6)
Wheat Germ Extract (1)
Purified (4)
ASGR2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His-SUMO, N-terminus + Myc, C-terminus
1 mg/$1,679; 100 µg/$500; 20 µg/$364
ASGR2 Protein - Purified recombinant protein ASGR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
20 µg/$1,107
ASGR2 Protein - Purified recombinant protein ASGR2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
32.9 kDa
20 µg/$1,107
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
32.4 kDa
20 µg/$150
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
35 kDa
20 µg/$150
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
32.9 kDa
20 µg/$150
ASGR2 Protein - Recombinant  Asialoglycoprotein Receptor 2 By SDS-PAGE
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E. coli
His-T7
38.9 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
ASGR2 Protein - 12.5% SDS-PAGE of human ASGR2 stained with Coomassie Blue
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Wheat Germ Extract
GST
57.31 kDa
10 µg/$479; 25 µg/$670
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
32.4 kDa
100 µg/$494
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
32.9 kDa
100 µg/$494
ASGR2 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
E. coli
10His, N-terminus + Myc, C-terminus
29.9 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
ASGR2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
35 kDa
100 µg/$494
ASGR2 Protein
Select
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).