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ASGR2

asialoglycoprotein receptor 2

ASGR2 is a subunit of the asialoglycoprotein receptor. This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. The protein encoded by this gene is the less abundant minor subunit. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene Name: asialoglycoprotein receptor 2
Synonyms: ASGR2, ASGPR2, Asialoglycoprotein receptors 2, ASGP-R 2, ASGPR 2, ASGP-R2, Asialoglycoprotein receptor 2, CLEC4H2, Hepatic lectin H2, HL-2, HBxAg-binding protein, HBXBP
Target Sequences: NM_001181 NP_001172.1 P07307

Publications (1)

1
Pattern-Specific Transcriptomics Identifies ASGR2 as a Predictor of Hematogenous Recurrence of Gastric Cancer. Tanaka H, Kanda M, Miwa T, Tanaka C, Kobayashi D, Umeda S, Shibata M, Suenaga M, Hattori N, Hayashi M, Iwata N, Yamada S, Nakayama G, Fujiwara M, Kodera Y. Molecular cancer research : MCR. 2018 September;16:1420-1429. [Full Text Article] [PubMed:29784667] Related Antibodies: LS-C196698.

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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).