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ASCC1
activating signal cointegrator 1 complex subunit 1
ASCC1 is a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
| Gene Name: | activating signal cointegrator 1 complex subunit 1 |
| Synonyms: | ASCC1, ASC1p50, ASC-1 complex subunit p50, p50, CGI-18, Em:AC022392.3, Trip4 complex subunit p50 |
| Target Sequences: | NM_015947 NP_057031.2 Q8N9N2 |
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