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ARRB2 / Beta Arrestin 2

arrestin, beta 2

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: arrestin, beta 2
Synonyms: ARRB2, Arrestin 3, Arrestin beta-2, ARB2, ARR2, BARR2, Arrestin, beta 2, Beta-arrestin-2
Target Sequences: NM_004313 NP_004304.1 P32121

Publications (4)

1
Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, Krasteva G, Wilhelm J, Dietrich H, Wilker S, Padberg W, Wygrecka M, Grau V. Immunobiology. 2011 216:854-61. [PubMed:21193245] Related Antibodies: LS-C54486.
2
Acute ethanol exposure reduces serotonin receptor 1A internalization by increasing ubiquitination and degradation of ß-arrestin2. Deborah J Luessen, Haiguo Sun, Molly M McGinnis, Michael Hagstrom, Glen Marrs, Brian A McCool, Rong Chen. The Journal of biological chemistry. 2019 September;294:14068-14080. [Full Text Article] [PubMed:31366729] [PMC:PMC6755807] Related Antibodies: LS-B6008.
3
Pioglitazone Enhances ß-Arrestin2 Signaling and Ameliorates Insulin Resistance in Classical Insulin Target Tissues. Shaimaa El-Fayoumi, Rehab Mansour, Amr Mahmoud, Ahmed Fahmy, Islam Ibrahim. Pharmacology. 2021 June;106:409-417. [Full Text Article] [PubMed:34082428]
4
Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia. Napolitano F, Pasqualetti M, Usiello A, Santini E, Pacini G, Sciamanna G, Errico F, Tassone A, Di Dato V, Martella G, Cuomo D, Fisone G, Bernardi G, Mandolesi G, Mercuri NB, Standaert DG, Pisani A. Neurobiology of disease. 2010 38:434-45. [PubMed:20227500] Related Antibodies: LS-C54486.
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ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Rabbit
1.25 - 80 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ARRB2 / Beta Arrestin 2 ELISA Kit
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96-Well Strip Plate
Chicken
1.563 - 100 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Monkey
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Porcine
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
31.2 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Microplate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
ARRB2 / Beta Arrestin 2 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
ARRB2 / Beta Arrestin 2 ELISA Kit
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Custom
96-Well Strip Plate
Colorimetric - 450nm (TMB)
1 Plate/$783
ARRB2 / Beta Arrestin 2 ELISA Kit
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Custom
96-Well Strip Plate
Rat
Colorimetric - 450nm (TMB)
1 Plate/$783
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich CLIA
12 x 8-Well Microstrips
Human
78.125 - 5000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
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96-Well Strip Plate
Rat
50 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
ARRB2 / Beta Arrestin 2 ELISA Kit
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96-Well Strip Plate
Human
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$913
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
ARRB2 / Beta Arrestin 2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
15.63 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).