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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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ARRB2 / Beta Arrestin 2

arrestin, beta 2

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene Name: arrestin, beta 2
Synonyms: ARRB2, Arrestin 3, Arrestin beta-2, ARB2, ARR2, BARR2, Arrestin, beta 2, Beta-arrestin-2
Target Sequences: NM_004313 NP_004304.1 P32121

Publications (2)

1
Reduced expression of arrestin beta 2 by graft monocytes during acute rejection of rat kidneys. Zakrzewicz A, Krasteva G, Wilhelm J, Dietrich H, Wilker S, Padberg W, Wygrecka M, Grau V. Immunobiology. 2011 216:854-61. [PubMed:21193245] Related Antibodies: LS-C54486.
2
Dopamine D2 receptor dysfunction is rescued by adenosine A2A receptor antagonism in a model of DYT1 dystonia. Napolitano F, Pasqualetti M, Usiello A, Santini E, Pacini G, Sciamanna G, Errico F, Tassone A, Di Dato V, Martella G, Cuomo D, Fisone G, Bernardi G, Mandolesi G, Mercuri NB, Standaert DG, Pisani A. Neurobiology of disease. 2010 38:434-45. [PubMed:20227500] Related Antibodies: LS-C54486.


ARRB2 / Beta Arrestin 2 Antibody - Anti-Beta-Arrestin 2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 3G1] (IgG2a,k) to Human ARRB2 / Beta Arrestin 2
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $495.00
ARRB2 / Beta Arrestin 2 Antibody - Anti-ARRB2 antibody IHC of human thyroid. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50µg   0.5mg/ml   $425.00
ARRB2 / Beta Arrestin 2 Antibody - Goat Anti-Arrestin beta 2 Antibody (4µg/ml) staining of paraffin embedded Human Cerebellum. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining. This data is from a previous batch, not on sale.
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Goat Polyclonal to Human ARRB2 / Beta Arrestin 2
Human
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
ARRB2 / Beta Arrestin 2 Antibody - Immunohistochemistry of paraffin-embedded human spleen tissue using CSB-PA002135LA01HU at dilution of 1:100
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100µg   $355.00
ARRB2 / Beta Arrestin 2 Antibody - Immunohistochemistry of paraffin-embedded human breast cancer tissue.
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Human
IF, IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $315.00; 200µl   $425.00
ARRB2 / Beta Arrestin 2 Antibody - 1:100 staining rat brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
ARRB2 / Beta Arrestin 2 Antibody - Detection of Human Beta-Arrestin 2 by Immunohistochemistry. Samples: FFPE sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Beta-Arrestin 2 used at a dilution of 1:1000. Detection: DAB.
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $405.00
ARRB2 / Beta Arrestin 2 Antibody - Antibody staining ARRB2 in human brain tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH 6). Samples were incubated with primary antibody (1:25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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Rabbit Polyclonal to Human ARRB2 / Beta Arrestin 2
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
200µl   $325.00
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta Arrestin 2 antibody. IHC(P): Human Intestinal Cancer Tissue.
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Rabbit Polyclonal to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
ARRB2 / Beta Arrestin 2 Antibody
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Rabbit Polyclonal to Human ARRB2 / Beta Arrestin 2
Human
ICC, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
ARRB2 / Beta Arrestin 2 Antibody - 1:100 staining rat liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Human
IF, IHC
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Human
IF, IHC
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
ARRB2 / Beta Arrestin 2 Antibody - Biotinylated antibody (1µg/ml) staining of Human Spleen lysate (35µg protein in RIPA buffer), exactly mirroring its parental non-biotinylated product. Primary incubation was 1 hour. Detected by chemiluminescence, using streptavidin-HRP and using NAP blocke
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Goat Polyclonal to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Human
IHC, IP, Peptide-ELISA, WB
Biotin Conjugated
100µg   0.5mg/ml   $405.00
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $365.00
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Rabbit, Dog, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $385.00
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Rabbit, Dog, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $385.00
ARRB2 / Beta Arrestin 2 Antibody - ARRB2 / Beta-Arrestin 2 antibody ARRB2(arrestin, beta 2) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Rabbit, Dog, Bovine, Pig, Horse, Bat, Gibbon, Orangutan, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $385.00
ARRB2 / Beta Arrestin 2 Antibody - Immunofluorescence (IF) analysis of HeLa cells using Arrestin-beta-2 Monoclonal Antibody.
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Mouse Monoclonal to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Pig, Human
IF, WB
Unconjugated
50µl   1mg/ml   $275.00; 100µl   1mg/ml   $345.00
ARRB2 / Beta Arrestin 2 Antibody - Detection of Human Beta-Arrestin 2 by Immunohistochemistry. Samples: FFPE sections of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Beta-Arrestin 2 used at a dilution of 1:1000 (1 ug/ml) (left). Detection: DAB.
Select
Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Human
IHC, IHC-P, IP
Unconjugated
100µl   1mg/ml   $405.00
ARRB2 / Beta Arrestin 2 Antibody - Western blot of ARRB2 pAb in extracts from Raw264.7 cells.
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Rabbit Polyclonal to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $385.00
Select
Rabbit Polyclonal to Human ARRB2 / Beta Arrestin 2
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   100µl   $345.00
Select
Goat Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Human
IHC, IHC-P
Unconjugated
100µg   $725.00
Select
Rabbit Polyclonal (IgG) to Human ARRB2 / Beta Arrestin 2
Human
WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).