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ARPP19

cAMP-regulated phosphoprotein, 19kDa

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. May indirectly enhance GAP-43 expression.

Gene Name:	cAMP-regulated phosphoprotein, 19kDa
Synonyms:	ARPP19, ARPP-16, ARPP16, ENSAL, ARPP-19
Target Sequences:	NM_006628 NP_006619.1 P56211

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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