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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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ARNTL / BMAL1

aryl hydrocarbon receptor nuclear translocator-like

ARNTL / BMAL1 is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

Gene Name: aryl hydrocarbon receptor nuclear translocator-like
Synonyms: ARNTL, BHLH-PAS protein JAP3, BHLHe5, BMAL1c, JAP3, PASD3, Member of PAS protein 3, MOP3, TIC, Brain and muscle ARNT-like 1, Member of PAS superfamily 3
Target Sequences: NM_001178 NP_001169.3 O00327

Publications (4)

1
Proxisome proliferator-activated receptor- mediates high-fat, diet-enhanced daily oscillation of plasminogen activator inhibitor-1 activity in mice. Hayashida S, Kuramoto Y, Koyanagi S, Oishi K, Fujiki J, Matsunaga N, Ikeda E, Ohdo S, Shimeno H, Soeda S. Chronobiology international. 2010 27:1735-53. (WB, ChrIP; Mouse) [PubMed:20969520]
2
Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src. Lauzier A, Charbonneau M, Harper K, Jilaveanu-Pelmus M, Dubois CM. Arthritis and rheumatism. 2011 63:1591-602. (ICC; Rat) [PubMed:21337539]
3
Dietary proanthocyanidins modulate BMAL1 acetylation, Nampt expression and NAD levels in rat liver. Ribas-Latre A, Baselga-Escudero L, Casanova E, Arola-Arnal A, Salvadó MJ, Bladé C, Arola L. Scientific reports. 2015 5:10954. (WB; Human) [Full Text Article] [PubMed:26051626] [PMC:PMC4603780] Related Antibodies: LS-C16603.
4
Expression of circadian clock genes and proteins in urothelial cancer is related to cancer-associated genes. Litlekalsoy J, Rostad K, Kalland KH, Hostmark JG, Laerum OD. BMC cancer. 2016 16:549. (WB, IHC-P; Mouse, Human) [Full Text Article] [PubMed:27465361] [PMC:PMC4964027]
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Viewing 1-25 of 64 items
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Mouse Monoclonal [clone 1C5] (IgG1) to Human ARNTL / BMAL1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 1C11] (IgG1) to Human ARNTL / BMAL1
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl   $425.00
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Rabbit Polyclonal to Human ARNTL / BMAL1
Human
ChrIP, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
Select
(1) Publication(s)
Rabbit Polyclonal (IgG) to Human ARNTL / BMAL1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   $725.00
ARNTL / BMAL1 Antibody - ARNTL / BMAL1 antibody ARP32002_T100-NP_001169-ARNTL (aryl hydrocarbon receptor nuclear translocator-like) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human skin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human ARNTL / BMAL1
Guinea pig, Sheep, Bovine, Pig, Horse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $335.00
ARNTL / BMAL1 Antibody - NIH 3T3 Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Mouse ARNTL / BMAL1
Rabbit, Mouse, Dog, Rat, Hamster
WB
Unconjugated
100µl   0.5mg/ml   $325.00
ARNTL / BMAL1 Antibody - IHC of paraffin-embedded Human lung tissue using anti-ARNTL mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI1H6] (IgG1) to Human ARNTL / BMAL1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
ARNTL / BMAL1 Antibody - IHC of paraffin-embedded Human lung tissue using anti-ARNTL mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI1H6] (IgG1) to Human ARNTL / BMAL1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Human ARNTL / BMAL1
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   $755.00
ARNTL / BMAL1 Antibody - Anti-ARNTL mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ARNTL.
Select
Mouse Monoclonal [clone OTI1D1] (IgG1) to Human ARNTL / BMAL1
Flo, IF, WB
Unconjugated
100µl   1mg/ml   $345.00
ARNTL / BMAL1 Antibody - Anti-ARNTL mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ARNTL.
Select
Mouse Monoclonal [clone OTI1D1] (IgG1) to Human ARNTL / BMAL1
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Drosophila ARNTL / BMAL1
Drosophila
ELISA, WB
Unconjugated
50µg   $635.00
ARNTL / BMAL1 Antibody - Antibody (0.3 ug/ml) staining of Human Brain (Cerebellum) lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
Select
Goat Polyclonal to Human ARNTL / BMAL1
Xenopus, Chicken, Sheep, Bovine, Rat, Hamster, Pig, Horse, Bat, Rabbit, Mouse, Dog, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100µg   0.5mg/ml   $405.00
ARNTL / BMAL1 Antibody - Anti-ARNTL mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ARNTL.
Select
Mouse Monoclonal [clone OTI3G9] (IgG1) to Human ARNTL / BMAL1
Flo, IF, WB
Unconjugated
100µl   1mg/ml   $345.00
ARNTL / BMAL1 Antibody - Anti-ARNTL mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY ARNTL.
Select
Mouse Monoclonal [clone OTI3G9] (IgG1) to Human ARNTL / BMAL1
Dog, Rat, Human
Flo, IF, WB
Unconjugated, Carrier-free
100µg   $395.00
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC staining of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 1C11] (IgG1) to Human ARNTL / BMAL1
Human
IF, IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Mouse Monoclonal (IgG1) to Human ARNTL / BMAL1
Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
ARNTL / BMAL1 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded Human Spleen tissues with AEC staining using BMAL1 Monoclonal Antibody.
Select
Mouse Monoclonal (IgG1) to Human ARNTL / BMAL1
Human
ELISA, IHC, WB
Unconjugated
100µl   $345.00
ARNTL / BMAL1 Antibody
Select
Rabbit Polyclonal (IgG) to Human ARNTL / BMAL1
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ARNTL / BMAL1
Mouse, Rat, Primate, Human
IHC, IHC-P, WB
Biotin Conjugated
100µl   $365.00
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ARNTL / BMAL1
Human
IHC, IHC-P, WB
DY650 Conjugated
100µl   $365.00
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ARNTL / BMAL1
Human
IHC, IHC-P, WB
DY488 Conjugated
100µl   $365.00
ARNTL / BMAL1 Antibody - Anti-ARNTL / BMAL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ARNTL / BMAL1
Human
IHC, IHC-P, WB
DY550 Conjugated
100µl   $365.00
ARNTL / BMAL1 Antibody - BMAL1 Antibody in Immunohistochemistry (IHC)
Select
Mouse Monoclonal [clone 1C5] (IgG1) to Human ARNTL / BMAL1
Human
IHC, WB
Unconjugated
100µl   $405.00
Select
Rabbit Polyclonal (IgG) to Human ARNTL / BMAL1
Human
ELISA, IP, WB
Unconjugated
100µg   $405.00

Viewing 1-25 of 64 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).