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ARMC10 is a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3.
Gene Name: | Armadillo Repeat Containing 10 |
Synonyms: | ARMC10, Armadillo repeat containing 10, PNAS-112, PNAS112, PSEC0198, SVH |
Target Sequences: | NM_031905 NP_114111.2 Q8N2F6 |
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