ARID1A / BAF250

AT rich interactive domain 1A (SWI-like)

Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

ARID1A / BAF250 (6)

Publications

No (6)

Tag

10His, N-terminus + Myc, C-terminus (2)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human ARID1A / BAF250 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88844

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

241.9 kDa

Price:

20 µg/$215

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Human ARID1A / BAF250 Protein (Recombinant His) (aa1201-1430) - LS-G141047

Source:

E. coli

Sequence Length:

229 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

25.3 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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Human ARID1A / BAF250 Protein (Recombinant GST, N-terminus) (aa1216-1325) - LS-G60675

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human ARID1A / BAF250 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G136829

Source:

Baculovirus

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

32.4 kDa

Price:

100 µg/$1,164; 20 µg/$475; 1 mg/$2,187

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Human ARID1A / BAF250 Protein (Recombinant 10His, N-terminus + Myc, C-terminus) - LS-G136957

Source:

E. coli

Tag:

10His, N-terminus + Myc, C-terminus

Molecular Weight:

33.4 kDa

Price:

1 mg/$1,679; 100 µg/$598; 20 µg/$405

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ARID1A / BAF250 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115547

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

241.9 kDa

Price:

100 µg/$710

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