ARHGEF18

Rho/Rac guanine nucleotide exchange factor (GEF) 18

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production.

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Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

ARHGEF18 (5)

Publications

No (5)

Tag

6His-SUMO, N-terminus (1)

GST (2)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (2)

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ARHGEF18 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G125165

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

130.6 kDa

Price:

100 µg/$710

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Human ARHGEF18 Protein (Recombinant GST) (aa159-551) - LS-G22274

Source:

E. coli

Tag:

GST

Molecular Weight:

71.9 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human ARHGEF18 Protein (Recombinant GST) (Full Length) - LS-G32813

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human ARHGEF18 Protein (Recombinant 6His-SUMO, N-terminus) - LS-G56493

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human ARHGEF18 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79917

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

130.6 kDa

Price:

20 µg/$215

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