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Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.
Gene Name: | Rho guanine nucleotide exchange factor (GEF) 16 |
Synonyms: | ARHGEF16, EPHEXIN4, GEF16, Ephexin-4, NBR |
Target Sequences: | NM_014448 NP_055263.2 Q5VV41 |
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