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20700 44th Avenue W
Lynnwood, WA 98036
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ARHGDIB / D4 GDI
Rho GDP dissociation inhibitor (GDI) beta
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).
| Gene Name: | Rho GDP dissociation inhibitor (GDI) beta |
| Synonyms: | ARHGDIB, D4 GDI, D4-GDI, GDIA2, Ly-GDI, RAP1GN1, Rho-GDI beta, RhoGDI2, Rho GDI 2, D4, GDID4, LYGDI |
| Target Sequences: | NM_001175 NP_001166.3 P52566 |
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