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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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ARHGAP10
Rho GTPase activating protein 10
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.
| Gene Name: | Rho GTPase activating protein 10 |
| Synonyms: | ARHGAP10, Graf-related protein 2, GRAF2, PSGAP, PS-GAP |
| Target Sequences: | NM_024605 NP_078881.3 A1A4S6 |
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