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ARHGAP10

Rho GTPase activating protein 10

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.

Gene Name:	Rho GTPase activating protein 10
Synonyms:	ARHGAP10, Graf-related protein 2, GRAF2, PSGAP, PS-GAP
Target Sequences:	NM_024605 NP_078881.3 A1A4S6

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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