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ARG1 / Arginase 1

arginase 1

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: arginase 1
Synonyms: ARG1, Arginase, liver, Arginase 1, Liver-type arginase, Liver arginase, Arginase-1, Type I arginase
Target Sequences: NM_000045 NP_000036.2 P05089

Publications (10)

1
Caffeine alters circadian rhythms and expression of disease and metabolic markers. Sherman H, Gutman R, Chapnik N, Meylan J, le Coutre J, Froy O. The international journal of biochemistry & cell biology. 2011 43:829-38. [PubMed:21352949]
2
All-trans retinoic acid modifies the expression of clock and disease marker genes. Sherman H, Gutman R, Chapnik N, Meylan J, le Coutre J, Froy O. The Journal of nutritional biochemistry. 2012 23:209-17. [PubMed:21497500]
3
Molecular imaging of the paracrine proangiogenic effects of progenitor cell therapy in limb ischemia. Ryu JC, Davidson BP, Xie A, Qi Y, Zha D, Belcik JT, Caplan ES, Woda JM, Hedrick CC, Hanna RN, Lehman N, Zhao Y, Ting A, Lindner JR. Circulation. 2013 127:710-9. (IHC-P; Mouse) [Full Text Article] [PubMed:23307829] [PMC:PMC3573704] Related Antibodies: LS-B4789.
4
Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts. van Straten G, van Steenbeek FG, Grinwis GC, Favier RP, Kummeling A, van Gils IH, Fieten H, Groot Koerkamp MJ, Holstege FC, Rothuizen J, Spee B. PloS one. 2014 9:e100077. (IHC; Canine) [Full Text Article] [PubMed:24945279] [PMC:PMC4063766]
5
Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R. Circulation research. 2014 115:662-7. (WB; Bovine) [Full Text Article] [PubMed:25070003]
6
The myeloid immune signature of enterotoxigenic Bacteroides fragilis-induced murine colon tumorigenesis. Thiele Orberg E, Fan H, Tam AJ, Dejea CM, Destefano Shields CE, Wu S, Chung L, Finard BB, Wu X, Fathi P, Ganguly S, Fu J, Pardoll DM, Sears CL, Housseau F. Mucosal immunology. 2017 March;10:421-433. (Human) [Full Text Article] [PubMed:27301879] [PMC:PMC5159334] Related Antibodies: LS-B4789.
7
Myelin basic protein charge isomers change macrophage polarization. Tsitsilashvili E, Sepashvili M, Chikviladze M, Shanshiashvili L, Mikeladze D. Journal of inflammation research. 2019 January;12:25-33. [Full Text Article] [PubMed:30774410] [PMC:PMC6350649]
8
Enhancement of radiosensitivity by the novel anticancer quinolone derivative vosaroxin in preclinical glioblastoma models. Gravina GL, Mancini A, Mattei C, Vitale F, Marampon F, Colapietro A, Rossi G, Ventura L, Vetuschi A, Di Cesare E, Fox JA, Festuccia C. Oncotarget. 2017 May;8:29865-29886. [Full Text Article] [PubMed:28415741] [PMC:PMC5444710]
9
Appearance of Alveolar Macrophage Subpopulations in Correlation With Histopathological Effects in Short-Term Inhalation Studies With Biopersistent (Nano)Materials. Johanna Koltermann-Jülly, Lan Ma-Hock, Sibylle Gröters, Robert Landsiedel. Toxicologic pathology. 2020 April;48:446-464. [Full Text Article] [PubMed:32162596] Related Antibodies: LS-B4660.
10
rhBMP2 alone does not induce macrophage polarization towards an increased inflammatory response. Emily L Durham, Rajiv Kishinchand, Zachary J Grey, James J Cray. Molecular immunology. 2020 January;117:94-100. [Full Text Article] [PubMed:31759326] [PMC:PMC6931256]
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Antibodies (181)
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ARG1 / Arginase 1 (228)
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ARG1 / Arginase 1 Antibody - Anti-ARG1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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ARG1 / Arginase 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$440
ARG1 / Arginase 1 Antibody - Anti-ARG1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ARG1 / Arginase 1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
ARG1 / Arginase 1 Antibody - Anti-ARG1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ARG1 / Arginase 1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$459
ARG1 / Arginase 1 Antibody - Anti-ARG1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
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ARG1 / Arginase 1 Goat anti-Human Polyclonal (aa311-324) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$440
ARG1 / Arginase 1 Antibody - ARG1 / Liver Arginase antibody ARG1(arginase, liver) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human lung.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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ARG1 / Arginase 1 Rabbit anti-Human Polyclonal (aa101-150) Antibody
Dog, Bovine, Rat, Pig, Horse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$387
ARG1 / Arginase 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 U/l
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
ARG1 / Arginase 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$809
ARG1 / Arginase 1 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$835
ARG1 / Arginase 1 Protein - Recombinant Arginase By SDS-PAGE
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E. coli
His, N-Terminal
36.5 kDa
10 µg/$258; 50 µg/$346; 100 µg/$550; 200 µg/$689; 1 mg/$1,615; 500 µg/$1,217; 5 mg/$3,405
ARG1 / Arginase 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$792
ARG1 / Arginase 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
3.12 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$746
ARG1 / Arginase 1 Protein - Recombinant Arginase By SDS-PAGE
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E. coli
6His, N-terminus
36.3 kDa
10 µg/$277; 50 µg/$460; 100 µg/$734; 200 µg/$917; 1 mg/$2,013; 500 µg/$1,482; 5 mg/$4,399
ARG1 / Arginase 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$903
ARG1 / Arginase 1 Protein
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Yeast
His
36.81 kD
100 µg/$489; 1 mg/$1,651; 20 µg/$354
ARG1 / Arginase 1 Antibody
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ARG1 / Arginase 1 Rabbit anti-Human Polyclonal (aa2-189) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µl/$317
ARG1 / Arginase 1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ARG1 / Arginase 1 Mouse anti-Human Monoclonal (aa1-322) (C7) Antibody
Human
ICC, IHC-P, IP, WB
Unconjugated
50 µl/$460
ARG1 / Arginase 1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Cancer Pathology
Cancer
ARG1 / Arginase 1 Mouse anti-Human Monoclonal (aa11-97) (ABM4B35) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$460
ARG1 / Arginase 1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Cancer Pathology
Cancer
ARG1 / Arginase 1 Mouse anti-Human Monoclonal (4E6) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$485
ARG1 / Arginase 1 Antibody - Formalin-fixed, paraffin-embedded human hepatocellular carcinoma stained with Arginase 1 antibody (ARG1/1125).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ARG1 / Arginase 1 Mouse anti-Human Monoclonal (aa1-150) (ARG1/1125) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$354; 100 µg/$550
ARG1 / Arginase 1 Antibody - IHC of paraffin-embedded Cal27 xenograft using arginase I antibody at 1:500 dilution.
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ARG1 / Arginase 1 Rabbit anti-Human Polyclonal (aa1-322) Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
100 µl/$398
ARG1 / Arginase 1 Antibody - IHC testing of FFPE human hepatocellular carcinoma and Arginase 1 antibody (clone T1ARG-1).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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ARG1 / Arginase 1 Mouse anti-Human Monoclonal (C-Terminus) (T1ARG-1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
20 µg/$354; 100 µg/$550
ARG1 / Arginase 1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
0.781 - 50 ng/ml
Chemiluminescent
Plasma, Serum
1 Plate/$776
ARG1 / Arginase 1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
3.125 - 200 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$693
ARG1 / Arginase 1 Protein
Select
E. coli
His
100 µg/$332; 500 µg/$602; 20 µg/$242
ARG1 / Arginase 1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
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ARG1 / Arginase 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC-P, IP, WB
Unconjugated
100 µg/$321
Viewing 1-25 of 228 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).