ARFGEF2 / BIG2

ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)

Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extend on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways.

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Products

Antibodies (12)

Type

Primary (12)

Target

ARFGEF2 / BIG2 (12)

Reactivity

Human (12)

Mouse (5)

Rat (5)

Application

IHC (5)

IHC-P (2)

WB (8)

ELISA (3)

IF (6)

IP (1)

Peptide-ELISA (2)

Host

rabbit (12)

Isotype

IgG (11)

Clonality

polyclonal pc (12)

Format

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

Unconjugated (9)

Epitope

aa300-350 (2)

1460-1540 aa, C-terminal (1)

Leu1527 (1)

aa1491-1540 (1)

Publications

No (12)

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ARFGEF2 / BIG2 Antibody (1460-1540 aa, C-terminal) LS-C382271

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (1460-1540 aa, C-terminal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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ARFGEF2 / BIG2 Antibody LS-C673673

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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ARFGEF2 / BIG2 Antibody (HRP) LS-C673674

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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ARFGEF2 / BIG2 Antibody (Biotin) LS-C673677

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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ARFGEF2 / BIG2 Antibody (FITC) LS-C673675

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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ARFGEF2 / BIG2 Antibody (Leu1527) LS-C177355

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (Leu1527) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$321; 100 µl/$403

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ARFGEF2 / BIG2 Antibody LS-C823898

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

100 µg/$357

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ARFGEF2 / BIG2 Antibody (aa1491-1540) LS-C119793

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (aa1491-1540) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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ARFGEF2 / BIG2 Antibody (aa300-350) LS-C287835

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (aa300-350) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

ARFGEF2 / BIG2 Antibody LS-C804873

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

ARFGEF2 / BIG2 Antibody (aa300-350) LS-C286757

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal (aa300-350) Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

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ARFGEF2 / BIG2 Antibody LS-C750355

Antibody:

ARFGEF2 / BIG2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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