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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

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Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ARA9 / AIP

aryl hydrocarbon receptor interacting protein

ARA9 / AIP is a receptor for aryl hydrocarbons and a ligand-activated transcription factor. The encoded protein is found in the cytoplasm as part of a multiprotein complex, but upon binding of ligand is transported to the nucleus. This protein can regulate the expression of many xenobiotic metabolizing enzymes. Also, the encoded protein can bind specifically to and inhibit the activity of hepatitis B virus. Three transcript variants encoding different isoforms have been found for this gene.

Gene Name: aryl hydrocarbon receptor interacting protein
Synonyms: AIP, FKBP16, Immunophilin homolog ARA9, HBV X-associated protein 2, XAP2, ARA9, FKBP37, SMTPHN, XAP-2
Target Sequences: NM_003977 NP_003968.3 O00170

Publications (11)

1
Subcellular localization of the aryl hydrocarbon receptor is modulated by the immunophilin homolog hepatitis B virus X-associated protein 2. Petrulis JR, Hord NG, Perdew GH. The Journal of biological chemistry. 2000 275:37448-53. [PubMed:10986286]
2
The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function. Hollingshead BD, Petrulis JR, Perdew GH. The Journal of biological chemistry. 2004 279:45652-61. [PubMed:15322122]
3
Role of endogenous XAP2 protein on the localization and nucleocytoplasmic shuttling of the endogenous mouse Ahb-1 receptor in the presence and absence of ligand. Pollenz RS, Wilson SE, Dougherty EJ. Molecular pharmacology. 2006 70:1369-79. [PubMed:16835354]
4
Expression of aryl hydrocarbon receptor (AHR) and AHR-interacting protein in pituitary adenomas: pathological and clinical implications. Jaffrain-Rea ML, Angelini M, Gargano D, Tichomirowa MA, Daly AF, Vanbellinghen JF, D'Innocenzo E, Barlier A, Giangaspero F, Esposito V, Ventura L, Arcella A, Theodoropoulou M, Naves LA, Fajardo C, Zacharieva S, Rohmer V, Brue T, Gulino A, Cantore G, Aless. Endocrine-related cancer. 2009 16:1029-43. (IHC-P; Human) [PubMed:19556287]
5
The expression of AIP-related molecules in elucidation of cellular pathways in pituitary adenomas. Helivaara E, Raitila A, Launonen V, Paetau A, Arola J, Lehtonen H, Sane T, Weil RJ, Vierimaa O, Salmela P, Tuppurainen K, Mkinen M, Aaltonen LA, Karhu A. The American journal of pathology. 2009 175:2501-7. (WB; Mouse, Human, Rat) [PubMed:19850893] [PMC:PMC2789606]
6
Isolated familial somatotropinoma: 11q13-loh and gene/protein expression analysis suggests a possible involvement of aip also in non-pituitary tumorigenesis. Toledo RA, Mendonca BB, Fragoso MC, Soares IC, Almeida MQ, Moraes MB, Loureno DM, Alves VA, Bronstein MD, Toledo SP. Clinics (So Paulo, Brazil). 2010 65:407-15. (IHC-P; Human) [PubMed:20454499] [PMC:PMC2862671]
7
Developmental control of apoptosis by the immunophilin aryl hydrocarbon receptor-interacting protein (AIP) involves mitochondrial import of the survivin protein. Kang BH, Xia F, Pop R, Dohi T, Socolovsky M, Altieri DC. The Journal of biological chemistry. 2011 286:16758-67. (WB; Mouse, Human) [PubMed:21454573] [PMC:PMC3089518]
8
The immunophilin-like protein XAP2 is a negative regulator of estrogen signaling through interaction with estrogen receptor . Cai W, Kramarova TV, Berg P, Korbonits M, Pongratz I. PloS one. 2011 6:e25201. (WB, IP, ChrIP; Human) [PubMed:21984905] [PMC:PMC3184960]
9
Somatostatin analogs modulate AIP in somatotroph adenomas: the role of the ZAC1 pathway. Chahal HS, Trivellin G, Leontiou CA, Alband N, Fowkes RC, Tahir A, Igreja SC, Chapple JP, Jordan S, Lupp A, Schulz S, Ansorge O, Karavitaki N, Carlsen E, Wass JA, Grossman AB, Korbonits M. The Journal of clinical endocrinology and metabolism. 2012 97:E1411-20. (IHC, WB; Human, Rat) [PubMed:22659247]
10
MicroRNA miR-107 is overexpressed in pituitary adenomas and inhibits the expression of aryl hydrocarbon receptor-interacting protein in vitro. Trivellin G, Butz H, Delhove J, Igreja S, Chahal HS, Zivkovic V, McKay T, Patcs A, Grossman AB, Korbonits M. American journal of physiology. Endocrinology and metabolism. 2012 303:E708-19. (WB; Human, Rat) [PubMed:22811466]
11
-Catenin signaling induces CYP1A1 expression by disrupting adherens junctions in Caco-2 human colon carcinoma cells. Pennacchio LA, Olivier M, Hubacek JA, Cohen JC, Cox DR, Fruchart JC, Krauss RM, Rubin EM. Biochimica et biophysica acta. 2012 1830:2509-2516. (WB; Human) [PubMed:23174221]
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Viewing 1-25 of 70 items
ARA9 / AIP Antibody - Anti-AIP antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human ARA9 / AIP
Rat, Pig, Horse, Bat, Dog, Bovine, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
ARA9 / AIP Antibody - Anti-AIP antibody IHC of human bile duct. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
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Mouse Monoclonal [clone 35-2] (IgG1) to Human ARA9 / AIP
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl   $425.00
ARA9 / AIP Antibody - Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Mouse, Human
ICC, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $485.00
ARA9 / AIP Antibody
Select
Rabbit Polyclonal to Human ARA9 / AIP
Rat, Human
ELISA, IHC, WB
Unconjugated
100µg   $275.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
ARA9 / AIP Antibody - Immunohistochemistry image of paraffin-embedded human adrenal gland tissue at a dilution of 1:100
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Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
ARA9 / AIP Antibody - AIP Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human rectum tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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Rabbit Polyclonal to Human ARA9 / AIP
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
ARA9 / AIP Antibody - AIP antibody ARP35710_T100-NP_003968-AIP (aryl hydrocarbon receptor interacting protein) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Zebrafish, Human
IHC, IHC-P, WB
Unconjugated
100µl   0.5mg/ml   $325.00
ARA9 / AIP Antibody - AIP antibody ARP35710_T100-NP_003968-AIP (aryl hydrocarbon receptor interacting protein) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Zebrafish, Chimpanzee, Human
IHC, IHC-P, WB
HRP Conjugated
100µl   0.65mg/ml   $335.00
ARA9 / AIP Antibody - AIP antibody ARP35710_T100-NP_003968-AIP (aryl hydrocarbon receptor interacting protein) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Zebrafish, Chimpanzee, Human
IHC, IHC-P, WB
Biotin Conjugated
100µl   1mg/ml   $335.00
ARA9 / AIP Antibody - AIP antibody ARP35710_T100-NP_003968-AIP (aryl hydrocarbon receptor interacting protein) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human kidney.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Zebrafish, Chimpanzee, Human
IHC, IHC-P, WB
FITC Conjugated
100µl   1mg/ml   $335.00
ARA9 / AIP Antibody
Select
Rabbit Polyclonal to Human ARA9 / AIP
Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $275.00
ARA9 / AIP Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY AIP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AIP.
Select
Mouse Monoclonal [clone OTI1B6] (IgG1) to Human ARA9 / AIP
Human
Flo, WB
Unconjugated
100µl   1mg/ml   $345.00
ARA9 / AIP Antibody - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY AIP (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-AIP.
Select
Mouse Monoclonal [clone OTI1B6] (IgG1) to Human ARA9 / AIP
Human
Flo, WB
Unconjugated, Carrier-free
100µg   $395.00
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Mouse, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
ARA9 / AIP Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using AIP Polyclonal Antibody at dilution of 1:80.
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Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   0.6mg/ml   $205.00; 60µl   0.6mg/ml   $235.00; 120µl   0.6mg/ml   $295.00; 200µl   0.6mg/ml   $395.00
Select
Mouse Monoclonal (IgG1) to Human ARA9 / AIP
Mouse, Human
ELISA, WB
Unconjugated
100µl   $530.00
Select
Mouse Monoclonal (IgG1,k) to Human ARA9 / AIP
Human
ELISA, WB
Unconjugated
100µg   $560.00
ARA9 / AIP Antibody - Immunohistochemistry of paraffin-embedded mouse kidney tissue.
Select
Rabbit Polyclonal (IgG) to Human ARA9 / AIP
Mouse, Human
IHC, WB
Unconjugated
50µl   $255.00; 100µl   $315.00; 200µl   $425.00

Viewing 1-25 of 70 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).