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AR / Androgen Receptor
androgen receptor
The androgen receptor (AR) is a NR3 Steroid Receptor located on the X chromosome. AR is a phosphoprotein and acts as a steroid hormone-activated transcription factor for androgen-responsive genes. Mutations in the AR gene are associated with androgen insensitivity syndrome (CAIS) or testicular feminization syndrome, Reifenstein syndrome, and Kennedy spinal and bulbar muscular atrophy. They lead to symptoms such as low virilization, reduced sperm production, testicular atrophy, and infertility. Androgen signaling through the androgen receptor (AR) appears to be involved in all aspects of prostate cancer, from initiation to development of treatment resistance. Gain-of-function AR gene mutations and/or altered signaling through AR have been suggested to contribute to disease progression. A recent study showed decreased expression of AR in response to incubation of LNCaP prostate carcinoma cells with PC-SPES, a mixture of eight herbs (Bonham et al. 2002). Two forms of AR that differ in their N termini have been isolated: AR A (87 kD), which is derived from translation of an internal methionine codon (met188), and AR B (110 kD). The two isoforms are expressed in similar tissues; however, AR B generally is the more abundant form.
| Gene Name: | androgen receptor |
| Family/Subfamily: | NHR , NR3 Steroid receptor |
| Synonyms: | AR, Androgen receptor, Dihydrotestosterone receptor, DHTR, AIS, KD, NR3C4, HUMARA, SBMA, TFM, SMAX1, HYSP1 |
| Target Sequences: | NM_000044 NP_000035.2 P10275 |
Publications (4)
1
Androgen receptor levels and association with PIK3CA mutations and prognosis in breast cancer. Gonzalez-Angulo AM, Stemke-Hale K, Palla SL, Carey M, Agarwal R, Meric-Berstam F, Traina TA, Hudis C, Hortobagyi GN, Gerald WL, Mills GB, Hennessy BT. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009 15:2472-8.
[PubMed:19276248]
2
Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice. Wang RS, Chang HY, Kao SH, Kao CH, Wu YC, Yeh S, Tzeng CR, Chang C. International journal of molecular sciences. 2015 16:9831-49. (ICC; Human)
[Full Text Article]
[PubMed:25941928]
[PMC:PMC4463620]
3
ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor. Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, Schoumacher M, Meyer R, Deeds J, Buchwalter G, Stams T, Keen N, Sellers WR, Brown M, Pagliarini RA. eLife. 2016 5: (WB; Human)
[Full Text Article]
[PubMed:27183006]
[PMC:PMC4909395]
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AR / Androgen Receptor
(169)
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Publications
No
(169)
AR / Androgen Receptor Rabbit anti-Human Monoclonal (N-Terminus) (SP107) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$548
AR / Androgen Receptor Rabbit anti-Human Monoclonal (C-Terminus) (SP242) Antibody
Human
IHC, IHC-P
Unconjugated
500 µl/$562
AR / Androgen Receptor Goat anti-Human Polyclonal (aa2-16) Antibody
Mouse, Dog, Bovine, Rat, Pig, Human
IF, IHC-P, Peptide-ELISA, WB
Unconjugated
100 µg/$503
AR / Androgen Receptor Rabbit anti-Human Polyclonal (pTyr267) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$567
AR / Androgen Receptor Mouse anti-Human Monoclonal (2H8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$460
AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa1-50) Antibody
Human
IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
![AR / Androgen Receptor Antibody - Immunoperoxidase of monoclonal antibody to AR on formalin-fixed paraffin-embedded human renal cell carcinoma tissue. [antibody concentration 3 ug/ml].](https://lsbio-7d62.kxcdn.com/image2/ar-androgen-receptor-antibody-clone-1g3-ls-c133049/50204_4834017.jpg)
AR / Androgen Receptor Mouse anti-Human Monoclonal (1G3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
AR / Androgen Receptor Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
AR / Androgen Receptor Mouse anti-Human Monoclonal (aa300-316) (Azide-free, BSA-free) (AR441) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free, BSA-free
100 µg/$574
AR / Androgen Receptor Mouse anti-Human Monoclonal (aa300-316) (Ready-to-Use) (AR441) Antibody
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7 ml/$574
AR / Androgen Receptor Mouse anti-Human Monoclonal (aa300-316) (AR441 + DHTR/882) Antibody
Human
IF, IHC, IHC-P
Unconjugated
20 µg/$371; 100 µg/$574
AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer515) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$440; 100 µg/$480
AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer650) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$315
AR / Androgen Receptor Mouse anti-Human Monoclonal (aa660-919) (TS106) Antibody
Human
IHC
Unconjugated
100 µg/$884
AR / Androgen Receptor Mouse anti-Human Monoclonal (aa661-920) (PE) (11n6) Antibody
Mouse, Rat, Human
Flo
PE Conjugated
100 Tests/$832
AR / Androgen Receptor Mouse anti-Human Monoclonal (aa661-920) (APC) (11n6) Antibody
Human
Flo
APC Conjugated
100 Tests/$907
AR / Androgen Receptor Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$321
AR / Androgen Receptor Mouse anti-Human Monoclonal (2H8) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
AR / Androgen Receptor Rabbit anti-Human Polyclonal (590-670 aa) Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
AR / Androgen Receptor Rabbit anti-Human Polyclonal (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
AR / Androgen Receptor Mouse anti-Human Monoclonal (Preservative Free) (3C6-F12-F11) Antibody
Human
ELISA, WB
Unconjugated, Preservative Free
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer94) Antibody
Mouse, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
AR / Androgen Receptor Rabbit anti-Human Polyclonal (aa621-670) Antibody
Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
AR / Androgen Receptor Rabbit anti-Mouse Polyclonal (aa156-310) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
AR / Androgen Receptor Rabbit anti-Human Polyclonal (pSer213) Antibody
Human, Monkey
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$263; 100 µl/$315; 200 µl/$379
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