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AQP2 / Aquaporin 2

aquaporin 2 (collecting duct)

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.

Gene Name: aquaporin 2 (collecting duct)
Family/Subfamily: Transporter , Aquaporin
Synonyms: AQP2, AQP-CD, ADH water channel, Aquaporin 2 (collecting duct), AQP-2, Aquaporin 2, Aquaporin-CD, Aquaporin-2, Water-channel aquaporin 2, WCH-CD
Target Sequences: NM_000486 NP_000477.1 P41181

Publications (9)

1
Vasopressin-stimulated increase in phosphorylation at Ser269 potentiates plasma membrane retention of aquaporin-2. Hoffert JD, Fenton RA, Moeller HB, Simons B, Tchapyjnikov D, McDill BW, Yu MJ, Pisitkun T, Chen F, Knepper MA. The Journal of biological chemistry. 2008 283:24617-27. [PubMed:18606813] [PMC:PMC2528999]
2
Serine 269 phosphorylated aquaporin-2 is targeted to the apical membrane of collecting duct principal cells. Moeller HB, Knepper MA, Fenton RA. Kidney international. 2009 75:295-303. [PubMed:18843259] [PMC:PMC3502047]
3
Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct. Yu MJ, Miller RL, Uawithya P, Rinschen MM, Khositseth S, Braucht DW, Chou CL, Pisitkun T, Nelson RD, Knepper MA. Proceedings of the National Academy of Sciences of the United States of America. 2009 106:2441-6. [PubMed:19190182] [PMC:PMC2650175]
4
Localization of aquaporins 1, 2, and 3 and vasopressin type 2 receptor in the mouse inner ear. Takumida M, Kakigi A, Egami N, Nishioka R, Anniko M. Acta oto-laryngologica. 2012 132:807-13. (ICC, IHC; Mouse) [PubMed:22768909]
5
Vasopressin increases S261 phosphorylation in AQP2-P262L, a mutant in recessive nephrogenic diabetes insipidus. Trimpert C, van den Berg DT, Fenton RA, Klussmann E, Deen PM. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2012 27:4389-97. (WB, DB; Dog) [PubMed:22778181]
6
Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. Toka HR, Al-Romaih K, Koshy JM, DiBartolo S, Kos CH, Quinn SJ, Curhan GC, Mount DB, Brown EM, Pollak MR. Journal of the American Society of Nephrology : JASN. 2012 23:1879-90. [PubMed:22997254] [PMC:PMC3482734]
7
Induction of metabolic acidosis with ammonium chloride (NH4Cl) in mice and rats--species differences and technical considerations. Nowik M, Kampik NB, Mihailova M, Eladari D, Wagner CA. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2011 26:1059-72. (WB; Rat) [Full Text Article] [PubMed:21220937]
8
Aquaporin-2 plays an important role in water transportation through the bladder wall in rats. Yosuke Morizawa, Kazumasa Torimoto, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Akihide Hirayama, Nobumichi Tanaka, Kiyohide Fujimoto. Neurourology and urodynamics. 2018 November;37:2434-2440. [Full Text Article] [PubMed:29797427] Related Antibodies: LS-C312893.
9
Sodium plays an important role in the absorption of intravesical fluid. Yosuke Morizawa, Kazumasa Torimoto, Shunta Hori, Daisuke Gotoh, Yasushi Nakai, Makito Miyake, Nobumichi Tanaka, Akihide Hirayama, Kiyohide Fujimoto. Lower urinary tract symptoms. 2021 Janurary;13:177-182. [Full Text Article] [PubMed:32410367] Related Antibodies: LS-C312893.
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Proteins (5)
Over-Expression Lysate (2)
Recombinant (3)
AQP2 / Aquaporin 2 (5)
No (5)
GST (1)
His (1)
His-GST (1)
Myc-DDK (Flag) (2)
Human (4)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (1)
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Low endotoxin level (1)
AQP2 / Aquaporin 2 Protein - 12.5% SDS-PAGE of human AQP2 stained with Coomassie Blue
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Human AQP2 / Aquaporin 2 Protein (Recombinant GST) (Full Length) - LS-G27495
Wheat Germ Extract
GST
55.2 kDa
10 µg/$479; 25 µg/$670
AQP2 / Aquaporin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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AQP2 / Aquaporin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G123166
HEK 293 Cells
Myc-DDK (Flag)
28.7 kDa
100 µg/$494
AQP2 / Aquaporin 2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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Human AQP2 / Aquaporin 2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74565
293T Cells
Myc-DDK (Flag)
28.7 kDa
20 µg/$150
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Human AQP2 / Aquaporin 2 Protein (Recombinant His) (aa200-271) - LS-G140979
E. coli
71 AA
His
Less than 0.1 EU/µg protein (determined by LAL method).
7.92 kDa
10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531
AQP2 / Aquaporin 2 Protein - Recombinant Aquaporin 2, Collecting Duct By SDS-PAGE
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Human AQP2 / Aquaporin 2 Protein (Recombinant His-GST) (aa177-271) - LS-G12418
E. coli
His-GST
42.6 kDa
10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148
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