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APOC3 / Apolipoprotein C III

apolipoprotein C-III

Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors.

Gene Name:	apolipoprotein C-III
Synonyms:	APOC3, Apo-CIII, Apolipoprotein C3, APOCIII, HALP2, ApoC-III, Apolipoprotein C-III
Target Sequences:	NM_000040 NP_000031.1 P02656

Publications (2)

Development of a sensitive ELISA to quantify apolipoprotein CIII in nonhuman primate serum. Wang Y, Song Z, Wagner JD, Pachuk C, Subramanian RR. Journal of lipid research. 2011 52:1265-71. [PubMed:21371998] [PMC:PMC3090247]

Lowering apolipoprotein CIII protects against high-fat diet-induced metabolic derangements. Ismael Valladolid-Acebes, Karin Åvall, Patricia Recio-López, Noah Moruzzi, Galyna Bryzgalova, Marie Björnholm, Anna Krook, Elena Fauste Alonso, Madelene Ericsson, Fredrik Landfors, Stefan K Nilsson, Per-Olof Berggren, Lisa Juntti-Berggren. Science advances. 2021 March;7:eabc2931. [Full Text Article] [PubMed:33712458] [PMC:PMC7954448]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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