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APOBEC1

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1

The apolipoprotein B mRNA editing protein (APOBEC1) is involved in the production of apolipoprotein B (apoB-)48 from apoB-100. APOBEC1 gene spans 18 kb and contains 5 exons, all of which are translated. The use of an alternative splice acceptor results in an alternative form APOBEC1 mRNA, which misses exon 2 causing a frameshift that produces a novel 36-amino acid peptide in which only the first 6-amino acids are shared with APOBEC1. The exon 2-skipped form accounts for approximately 50% of mRNA in the adult small intestine and up to 90% of APOBEC1 mRNA in the developing gut. Exon 2-skipping may thus be a quantitatively important mechanism regulating the expression on APOBEC1 in the gastrointestinal tract.

Gene Name: Apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
Synonyms: APOBEC1, HEPR, APOBEC-1, BEDP, CDAR1
Target Sequences: NM_001644 NP_001635.2 P41238

Publications (1)

1
Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis. Kristensen DG, Nielsen JE, Jørgensen A, Skakkebæk NE, Rajpert-De Meyts E, Almstrup K. British journal of cancer. 2014 110:668-78. (WB, ELISA; Human) [Full Text Article] [PubMed:24292451] [PMC:PMC3915112] Related Antibodies: LS-C98890.

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Antibodies (16)
Primary (16)
APOBEC1 (16)
Human (16)
Mouse (10)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Horse (3)
Orangutan (3)
Pig (3)
IHC (7)
IHC-P (1)
WB (12)
ELISA (6)
IF (1)
Peptide-ELISA (1)
rabbit (15)
goat (1)
IgG (10)
polyclonal pc (16)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (5)
aa7-36 (7)
N-Terminus (4)
aa24-37 (1)
No (15)
Yes (1)
APOBEC1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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APOBEC1 Rabbit anti-Human Polyclonal (aa7-36) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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APOBEC1 Rabbit anti-Human Polyclonal (aa7-36) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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APOBEC1 Rabbit anti-Human Polyclonal (aa7-36) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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APOBEC1 Rabbit anti-Human Polyclonal (aa7-36) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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APOBEC1 Rabbit anti-Human Polyclonal (aa7-36) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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APOBEC1 Rabbit anti-Human Polyclonal (aa7-36) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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APOBEC1 Rabbit anti-Human Polyclonal (aa7-36) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
APOBEC1 Antibody - Immunofluorescence staining of HepG2 cells at a dilution of 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4 °C.The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L) .
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APOBEC1 Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
50 µg/$294; 100 µg/$360
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APOBEC1 Rabbit anti-Human Polyclonal (HRP) Antibody
Human
HRP Conjugated
50 µg/$294; 100 µg/$360
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APOBEC1 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
Biotin Conjugated
50 µg/$294; 100 µg/$360
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APOBEC1 Rabbit anti-Human Polyclonal (FITC) Antibody
Human
FITC Conjugated
50 µg/$294; 100 µg/$360
APOBEC1 Antibody - Antibody (1 ug/ml) staining of Mouse Spleen lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence
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APOBEC1 Goat anti-Human Polyclonal (aa24-37) Antibody
Mouse, Human
Peptide-ELISA, WB
Unconjugated
100 µg/$503
APOBEC1 Antibody - APOBEC1 antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
APOBEC1 Antibody - APOBEC1 antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC1 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Mouse, Dog, Pig, Horse, Orangutan, Gibbon, Human, Chimpanzee
WB
HRP Conjugated
100 µl/$469
APOBEC1 Antibody - APOBEC1 antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC1 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Mouse, Dog, Pig, Horse, Orangutan, Gibbon, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
APOBEC1 Antibody - APOBEC1 antibody Western blot of Fetal Liver lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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APOBEC1 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Mouse, Dog, Pig, Horse, Orangutan, Gibbon, Human, Chimpanzee
WB
FITC Conjugated
100 µl/$469
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).