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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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APOA1 / Apolipoprotein A 1

apolipoprotein A-I

APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18-amino acid signal peptide is removed co-translationally and a 6-amino acid propeptide is cleaved post-translationally. Variation in the latter step, in addition to modifications leading to so-called isoforms, is responsible for some of the polymorphism observed. APOA1 is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the C-III gene is transcribed convergently in relation to A-I. Defects in the apolipoprotein A-1 gene are associated with HDL deficiency and Tangier disease.

Gene Name: apolipoprotein A-I
Synonyms: APOA1, ApoA-I, APOAI, Apolipoprotein A-I, Apolipoprotein A1, Apo-AI
Target Sequences: NM_000039 NP_000030.1 P02647

Publications (5)

1
Characterization of nascent HDL particles and microparticles formed by ABCA1-mediated efflux of cellular lipids to apoA-I. Duong PT, Collins HL, Nickel M, Lund-Katz S, Rothblat GH, Phillips MC. Journal of lipid research. 2006 47:832-43. [PubMed:16418537]
2
A microbial TLR2 agonist imparts macrophage-activating ability to apolipoprotein A-1. Hasebe A, Pennock ND, Mu HH, Chan FV, Taylor ML, Cole BC. Journal of immunology (Baltimore, Md. : 1950). 2006 177:4826-32. [PubMed:16982924]
3
Tmprss3 loss of function impairs cochlear inner hair cell Kcnma1 channel membrane expression. Molina L, Fasquelle L, Nouvian R, Salvetat N, Scott HS, Guipponi M, Molina F, Puel JL, Delprat B. Human molecular genetics. 2013 22:1289-99. (ICC, IHC; Mouse) [PubMed:23255163]
4
Endothelial activation, haemostasis and thrombosis biomarkers in Ugandan children with severe malaria participating in a clinical trial. Graham SM, Chen J, Chung DW, Barker KR, Conroy AL, Hawkes MT, Namasopo S, Kain KC, López JA, Liles WC. Malaria journal. 2016 15:56. (ELISA; Human) [Full Text Article] [PubMed:26830467] [PMC:PMC4736470] Related Antibodies: LS-C11247, LS-C11248.
5
Von Willebrand Factor Adhesive Activity and ADAMTS13 Protease Activity in HIV-1-Infected Men. Graham SM, Chen J, Le J, Ling M, Chung DW, Liles WC, López JA. International journal of medical sciences. 2019 January;16:276-284. [Full Text Article] [PubMed:30745808] [PMC:PMC6367531] Related Antibodies: LS-C11247.
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Viewing 1-25 of 292 items
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human APOA1 / Apolipoprotein A 1
Human
ICC, IHC, IHC-P, WB
Unconjugated
1ea   $425.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC of mouse kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Mouse APOA1 / Apolipoprotein A 1
Mouse
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   1mg/ml   $425.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC of mouse liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Mouse APOA1 / Apolipoprotein A 1
Mouse, Rat
ELISA, ID, IHC, IHC-P, WB
Unconjugated
125µg   1mg/ml   $525.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-APOA1 / Apolipoprotein A 1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
Select
Mouse Monoclonal [clone 464CT10.4.4] (IgG1) to Human APOA1 / Apolipoprotein A 1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200µl   $425.00
Select
(2) Publication(s)
Mouse Monoclonal [clone G2] (IgG1) to Human APOA1 / Apolipoprotein A 1
Human
ELISA, IHC-Fr, WB
Unconjugated
0.5mg   $455.00
Select
(1) Publication(s)
Sheep Polyclonal (IgG) to Human APOA1 / Apolipoprotein A 1
Human
ELISA, WB
HRP Conjugated
0.2mg   $355.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal (IgG) to Human APOA1 / Apolipoprotein A 1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   0.5mg/ml   $425.00
Select
Goat Polyclonal to Human APOA1 / Apolipoprotein A 1
Human
ELISA, Flo, ID, IHC, IP, WB
Unconjugated
1mg   3.53mg/ml   $285.00
APOA1 / Apolipoprotein A 1 Antibody - Western blot of recombinant APOA1 / Apolipoprotein A 1.
Select
Mouse Monoclonal (IgG) to Rabbit APOA1 / Apolipoprotein A 1
Rabbit
WB
Unconjugated
20µl   1mg/ml   $205.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $305.00; 1ml   1mg/ml   $545.00
Select
Rabbit Polyclonal to Human APOA1 / Apolipoprotein A 1
Mouse, Rat, Human
IP
Magnetic beads Conjugated
100µg   $325.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC of mouse liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Mouse APOA1 / Apolipoprotein A 1
Mouse
ELISA, IHC, IHC-P, WB
Unconjugated
50µg   0.575mg/ml   $425.00
Select
Chicken Polyclonal to Human APOA1 / Apolipoprotein A 1
Chicken, Human
IHC, WB
Unconjugated
100µg   100µl   $375.00
APOA1 / Apolipoprotein A 1 Antibody - APOA1 / APOAI antibody Western blot of Rat Muscle lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat APOA1 / Apolipoprotein A 1
Rabbit, Dog, Bovine, Rat, Pig, Human
WB
Unconjugated
100µl   0.5mg/ml   $385.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal (IgG) to Human APOA1 / Apolipoprotein A 1
Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µg   1mg/ml   $425.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal [clone 057-10029] (IgG2a,k) to Human APOA1 / Apolipoprotein A 1
Human
ELISA, IHC, IHC-P, RIA
Unconjugated
50µg   1mg/ml   $425.00
APOA1 / Apolipoprotein A 1 Antibody - Apolipoprotein A I was detected in paraffin-embedded sections of mouse liver tissues using rabbit anti- Apolipoprotein A I Antigen Affinity purified polyclonal antibody at 1 ug/mL. The immunohistochemical section was developed using SABC method.
Select
Rabbit Polyclonal to Mouse APOA1 / Apolipoprotein A 1
Mouse
IHC, IHC-P, WB
Unconjugated
100µg   $355.00
Select
Goat Polyclonal to Human APOA1 / Apolipoprotein A 1
Human
ELISA, WB
Biotin Conjugated
1ml   $800.00
APOA1 / Apolipoprotein A 1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human APOA1 / Apolipoprotein A 1
Mouse, Rat, Human
WB
Unconjugated
100µg   1mg/ml   $295.00
APOA1 / Apolipoprotein A 1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human APOA1 / Apolipoprotein A 1
Mouse, Rat, Human
IP, WB
Sepharose Conjugated
100µg   $325.00
APOA1 / Apolipoprotein A 1 Antibody - Formalin-fixed and paraffin-embedded human Placenta tissue reacted with APOA1 antibody , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Select
Rabbit Polyclonal to Human APOA1 / Apolipoprotein A 1
Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
APOA1 / Apolipoprotein A 1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE), at a dilution of 1:200.
Select
Rabbit Polyclonal (IgG) to Human APOA1 / Apolipoprotein A 1
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
APOA1 / Apolipoprotein A 1 Antibody - Immunofluorescence of ApoA1 in Human Liver cells with ApoA1 antibody at 20 ug/ml.
Select
Chicken Polyclonal (IgY) to Human APOA1 / Apolipoprotein A 1
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
0.1mg   1mg/ml   $365.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-APOA1 / Apolipoprotein A 1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Select
Mouse Monoclonal (IgG2a,k) to Human APOA1 / Apolipoprotein A 1
Human
ELISA, IHC, IHC-P, RIA
Unconjugated
0.5mg   5mg/ml   $525.00
APOA1 / Apolipoprotein A 1 Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Mouse Monoclonal [clone 2G4] (IgG1,k) to Human APOA1 / Apolipoprotein A 1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
APOA1 / Apolipoprotein A 1 Antibody - Anti-Apolipoprotein A I antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal to Hamster APOA1 / Apolipoprotein A 1
Hamster, Human
ID, IE, IHC, IHC-P, WB
Unconjugated
50µl   $425.00

Viewing 1-25 of 292 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).