Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A.
|Gene Name:||APH1B gamma secretase subunit|
|Synonyms:||APH1B, Aph-1beta, APH-1B, Gamma-secretase subunit APH-1B, PRO1328, PSFL, TAAV688|
|Target Sequences:||NM_031301 NP_112591.2 Q8WW43|
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