Apg7 / ATG7

autophagy related 7

E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

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Products

Proteins (8)

Type

Over-Expression Lysate (4)

Recombinant (4)

Target

Apg7 / ATG7 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (5)

Mouse (1)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Mouse Apg7 / ATG7 Protein (Recombinant His-T7) (aa477-698) - LS-G26096

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.8 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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Human Apg7 / ATG7 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G61551

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human Apg7 / ATG7 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G68837

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.8 kDa

Price:

20 µg/$1,107

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Human Apg7 / ATG7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83207

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.8 kDa

Price:

20 µg/$215

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Human Apg7 / ATG7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G83205

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.4 kDa

Price:

20 µg/$150

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Human Apg7 / ATG7 Protein (Recombinant GST) (Full Length) - LS-G32202

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

104.4 kDa

Price:

10 µg/$479; 25 µg/$670

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Apg7 / ATG7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100812

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

77.8 kDa

Price:

100 µg/$710

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Apg7 / ATG7 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G126402

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

68.4 kDa

Price:

100 µg/$494

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