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APCL / APC2

adenomatosis polyposis coli 2

Promotes rapid degradation of CTNNB1 and may function as a tumor suppressor. May function in Wnt signaling.

Gene Name: adenomatosis polyposis coli 2
Synonyms: APC2, Adenomatosis polyposis coli 2, APC-like, APCL
Target Sequences: NM_005883 NP_005874.1 O95996

Publications (2)

1
Mass spectrometric analysis of the anaphase-promoting complex from yeast: identification of a subunit related to cullins. Zachariae W, Shevchenko A, Andrews PD, Ciosk R, Galova M, Stark MJ, Mann M, Nasmyth K. Science (New York, N.Y.). 1998 279:1216-9. [PubMed:9469814]
2
Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW. Science (New York, N.Y.). 1998 279:1219-22. [PubMed:9469815]

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).