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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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APBA2
amyloid beta (A4) precursor protein-binding, family A, member 2
APBA2 is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. Multiple transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | amyloid beta (A4) precursor protein-binding, family A, member 2 |
| Synonyms: | APBA2, D15S1518E, Adapter protein X11beta, LIN-10, MGC:14091, Mint-2, MINT2, X11-BETA, X11-like, HsT16821, Neuron-specific X11L protein, X11-like protein, X11L |
| Target Sequences: | NM_005503 NP_005494.2 Q99767 |
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