APAF1 / APAF-1

apoptotic peptidase activating factor 1

Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.

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Products

Proteins (7)

Type

Over-Expression Lysate (3)

Recombinant (4)

Target

APAF1 / APAF-1 (7)

Publications

No (7)

Tag

8His, N-terminus (1)

GST, N-terminus (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (5)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Yeast (1)

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Human APAF1 / APAF-1 Protein (Over-Expression Lysate 8His, N-terminus) (Asp2-Cys450) - LS-G26690

Source:

HEK 293 Cells

Tag:

8His, N-terminus

Molecular Weight:

52.6 kDa

Price:

100 µg/$298

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APAF1 / APAF-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104324

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.8 kDa

Price:

100 µg/$494

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Human APAF1 / APAF-1 Protein (Recombinant His) (aa104-415) - LS-G22800

Source:

Yeast

Tag:

His

Molecular Weight:

37.38 kD

Price:

100 µg/$570; 20 µg/$395; 1 mg/$1,973

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Human APAF1 / APAF-1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G74560

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.8 kDa

Price:

20 µg/$150

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Human APAF1 / APAF-1 Protein (Recombinant GST, N-terminus) (aa1138-1237) - LS-G57775

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human APAF1 / APAF-1 Protein (Recombinant His-T7) (aa31-350) - LS-G13281

Source:

E. coli

Tag:

His-T7

Molecular Weight:

39.6 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse APAF1 / APAF-1 Protein (Recombinant His) (aa872-1135) - LS-G13283

Source:

E. coli

Tag:

His

Molecular Weight:

30.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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