AP2S1

adaptor-related protein complex 2, sigma 1 subunit

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein Transport via Transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). May also play a role in extracellular calcium homeostasis.

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Products

Antibodies (15)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (15)

Recombinant (2)

Target

AP2S1 (19)

Reactivity

Human (15)

Mouse (1)

Rat (1)

Application

IHC (4)

WB (15)

ELISA (11)

IF (1)

Peptide-ELISA (1)

RNAi (1)

Host

rabbit (14)

mouse (1)

Isotype

IgG (12)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (14)

Clone

3E4 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (7)

Epitope

aa36-64 (7)

Publications

No (19)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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AP2S1 Antibody (clone 3E4) LS-C196929

Antibody:

AP2S1 Mouse anti-Human Monoclonal (3E4) Antibody

Reactivity:

Human

Applications:

ELISA, RNAi, WB

Format:

Unconjugated

Price:

100 µg/$423

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AP2S1 Antibody LS-C211718

Antibody:

AP2S1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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AP2S1 Antibody (HRP) LS-C211717

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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AP2S1 Antibody (Biotin) LS-C211720

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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AP2S1 Antibody (FITC) LS-C211719

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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AP2S1 Antibody LS-C806906

Antibody:

AP2S1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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AP2S1 Antibody (aa36-64) LS-C319512

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (aa36-64) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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AP2S1 Antibody (aa36-64, Biotin) LS-C251464

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (aa36-64) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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AP2S1 Antibody (aa36-64, FITC) LS-C251463

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (aa36-64) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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AP2S1 Antibody (aa36-64, PE) LS-C251466

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (aa36-64) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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AP2S1 Antibody (aa36-64, APC) LS-C251462

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (aa36-64) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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AP2S1 Antibody (aa36-64, Azide-free, HRP) LS-C251465

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (aa36-64) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

AP2S1 Antibody (aa36-64) LS-C159081

Antibody:

AP2S1 Rabbit anti-Human Polyclonal (aa36-64) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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AP2S1 Antibody LS-C667742

Antibody:

AP2S1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

Select

AP2S1 Antibody LS-C747419

Antibody:

AP2S1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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AP2S1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116892

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.8 kDa

Price:

100 µg/$494

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Human AP2S1 Protein (Recombinant GST) (Full Length) - LS-G27939

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.36 kDa

Price:

10 µg/$479; 25 µg/$670

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Human AP2S1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75192

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.8 kDa

Price:

20 µg/$150

Select

Human AP2S1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65260

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

16.8 kDa

Price:

20 µg/$1,107

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