AP2A1 / AP2-Alpha

adaptor-related protein complex 2, alpha 1 subunit

Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

AP2A1 / AP2-Alpha (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human AP2A1 / AP2-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85217

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

107.4 kDa

Price:

20 µg/$215

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AP2A1 / AP2-Alpha Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114104

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

107.4 kDa

Price:

100 µg/$710

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Human AP2A1 / AP2-Alpha Protein (Recombinant GST, N-terminus) (aa824-923) - LS-G57723

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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