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AOC3 / VAP-1 is a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants.
|Gene Name:||amine oxidase, copper containing 3|
|Synonyms:||AOC3, Copper amine oxidase, HPAO, Membrane primary amine oxidase, SSAO, VAP-1, VAP1, Vascular adhesion protein 1|
|Target Sequences:||NM_003734 NP_003725.1 Q16853|
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