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ANXA6/Annexin A6/Annexin VI
annexin A6
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kD that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Exon 21 of annexin VI is alternatively spliced, giving rise to two isoforms that differ by a 6-amino acid insertion at the start of the seventh repeat. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.
| Gene Name: | annexin A6 |
| Synonyms: | ANXA6, 67 kDa calelectrin, Annexin VI (p68), Annexin A6, Annexin VI, ANX6, Calcium-binding protein p68, Calelectrin, CBP68, Chromobindin-20, Calphobindin-II, Lipocortin VI, p70, Protein III, Annexin-6, Calphobindin II, CPB-II, p68 |
| Target Sequences: | NM_001155 NP_001146.2 P08133 |
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