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Antithrombin-III

serpin peptidase inhibitor, clade C (antithrombin), member 1

SERPINC1 / Antithrombin III is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.

Gene Name: serpin peptidase inhibitor, clade C (antithrombin), member 1
Synonyms: SERPINC1, Antithrombin III, Antithrombin-III, ATIII, AT3, Serpin C1, AT3D, THPH7
Target Sequences: NM_000488 NP_000479.1 P01008

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Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
Antithrombin-III (6)
No (6)
GST (1)
His (2)
Myc-DDK (Flag) (3)
Human (5)
293T Cells (1)
E. coli (1)
HEK 293 Cells (2)
Human Cells (1)
Wheat Germ Extract (1)
Purified (2)
Low endotoxin level (1)
Antithrombin-III Protein - Purified recombinant protein SERPINC1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
49 kDa
20 µg/$1,107
Antithrombin-III Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.6 kDa
20 µg/$215
Antithrombin-III Protein - 12.5% SDS-PAGE of human SERPINC1 stained with Coomassie Blue
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Wheat Germ Extract
GST
54.23 kDa
10 µg/$479; 25 µg/$670
Antithrombin-III Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
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Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
50.5 kDa
50 µg/$854
Antithrombin-III Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
52.6 kDa
100 µg/$710
Viewing 1-6 of 6 product results


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Products: Proteins


If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).