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2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
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Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
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Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
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Additional Contact Details
order histories, retained contact details for faster checkout, review submissions, and special promotions.
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Antithrombin-III
serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINC1 / Antithrombin III is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. More than 120 mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency.
| Gene Name: | serpin peptidase inhibitor, clade C (antithrombin), member 1 |
| Synonyms: | SERPINC1, Antithrombin III, Antithrombin-III, ATIII, AT3, Serpin C1, AT3D, THPH7 |
| Target Sequences: | NM_000488 NP_000479.1 P01008 |
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