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ANGPTL3 encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
Gene Name: | angiopoietin-like 3 |
Synonyms: | ANGPTL3, ANGPT5, ANG-5, Angiopoietin-5, Angiopoietin-like 3, Angiopoietin-related protein 3, FHBL2, Angiopoietin 5, Angiopoietin-like protein 3 |
Target Sequences: | NM_014495 NP_055310.1 Q9Y5C1 |
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