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ANGPT2 / Angiopoietin-2
angiopoietin 2
Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.
| Gene Name: | angiopoietin 2 |
| Synonyms: | ANGPT2, AGPT2, Angiopoietin-2, Angiopoietin-2a, Angiopoietin-2B, ANG-2, Angiopoietin 2, ANG2, Tie2-ligand |
| Target Sequences: | NM_001147 NP_001138.1 O15123 |
Publications (1)
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