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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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ANGPT1 / Angiopoietin-1

angiopoietin 1

Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.

Gene Name: angiopoietin 1
Synonyms: ANGPT1, Angiopoietin 1, Angiopoietin-1, AGPT, AGP1, ANG-1, ANG1, KIAA0003
Target Sequences: NM_001146 NP_001137.2 Q15389

Publications (1)

1
Blockade of vascular endothelial growth factor receptor 2 inhibits intraplaque haemorrhage by normalization of plaque neovessels. de Vries MR, Parma L, Peters HAB, Schepers A, Hamming JF, Jukema JW, Goumans MJTH, Guo L, Finn AV, Virmani R, Ozaki CK, Quax PHA. Journal of internal medicine. 2019 January;285:59-74. [Full Text Article] [PubMed:30102798] [PMC:PMC6334526] Related Antibodies: LS-B62.

Viewing 1-25 of 137 items
ANGPT1 / Angiopoietin-1 Antibody - Anti-ANGPT1 / Angiopoietin-1 antibody IHC staining of human lung, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Select
Rabbit Polyclonal to Mouse ANGPT1 / Angiopoietin-1
Mouse, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50µl   80mg/ml   $425.00
ANGPT1 / Angiopoietin-1 Antibody - Anti-ANGPT1 / Angiopoietin-1 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
Goat Polyclonal to Human ANGPT1 / Angiopoietin-1
Rabbit, Mouse, Dog, Horse, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
ANGPT1 / Angiopoietin-1 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
100µl   1mg/ml   $505.00
ANGPT1 / Angiopoietin-1 Antibody - Anti-Angiogenin / ANG antibody IHC staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal to Human ANGPT1 / Angiopoietin-1
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
ANGPT1 / Angiopoietin-1 Antibody - Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
ANGPT1 / Angiopoietin-1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Human ANGPT1 / Angiopoietin-1
Human
IHC, IHC-P, WB
Unconjugated
100µg   1mg/ml   $295.00
ANGPT1 / Angiopoietin-1 Antibody - ANGPT1 / ANG1 / Angiopoietin-1 antibody Western Blot of Mouse Liver.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Mouse ANGPT1 / Angiopoietin-1
Xenopus, Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Pig, Horse, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
ANGPT1 / Angiopoietin-1 Antibody - Western blot of recombinant ANGPT1 / ANG1 / Angiopoietin-1.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal to Rat ANGPT1 / Angiopoietin-1
Rat
WB
Unconjugated
100µl   0.5mg/ml   $255.00; 200µl   0.5mg/ml   $295.00; 500µl   0.5mg/ml   $435.00; 1ml   0.5mg/ml   $515.00
ANGPT1 / Angiopoietin-1 Antibody
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Mouse, Human
ELISA, IHC, WB
Unconjugated
100µl   1mg/ml   $265.00
ANGPT1 / Angiopoietin-1 Antibody - Angiopoietin 1 antibody IHC-paraffin: Human Lung Cancer Tissue.
Select
Rabbit Polyclonal to Human ANGPT1 / Angiopoietin-1
Mouse, Bovine, Rat, Pig, Orangutan, Gibbon, Chimpanzee, Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg   0.5mg/ml   $355.00
ANGPT1 / Angiopoietin-1 Antibody - Immunofluorescent analysis of Angiopoietin-1 staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
Select
Rabbit Polyclonal to Human ANGPT1 / Angiopoietin-1
Mouse, Bovine, Rat, Pig, Human
ICC, IF, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
ANGPT1 / Angiopoietin-1 Antibody - Western blot analysis of Angiopoietin-1 using anti-Angiopoietin-1 antibody. Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. lane 1: recombinant human ANGPT1 protein 1ng After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-Angiopoietin-1 antigen affinity purified polyclonal antibody at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1% Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit with Tanon 5200 system. A specific band was detected for Angiopoietin-1 at approximately 70KD. The expected band size for Angiopoietin-1 is at 57KD.
Select
Mouse Monoclonal to Human ANGPT1 / Angiopoietin-1
Human
ELISA, WB
Unconjugated
100µg   $325.00
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Human
WB
Unconjugated
100µl   $405.00
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Human
ELISA, IF, IHC, WB
HRP Conjugated, Lyophilized
100µg   1mg/ml   $425.00
ANGPT1 / Angiopoietin-1 Antibody - Immunohistochemistry of Ang-1 antibody
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal to Mouse ANGPT1 / Angiopoietin-1
Mouse
ELISA, IHC, WB
Unconjugated
100µg   $725.00
ANGPT1 / Angiopoietin-1 Antibody - Anti-ANG1 antibody was diluted 1:500 to detect ANG1 in human lung tissue. Tissue was formalin fixed and paraffin embedded. No pre-treatment of sample was required. The image shows the localization of antibody as the precipitated red signal, with a hematoxylin purple nuclear counter stain.
Select
Rabbit Polyclonal to Mouse ANGPT1 / Angiopoietin-1
Mouse, Human
ELISA, IHC, WB
Unconjugated
25µl   80mg/ml   $235.00
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Human
ELISA, IHC, WB
Unconjugated
100µg   $435.00
ANGPT1 / Angiopoietin-1 Antibody - IHC of paraffin-embedded Carcinoma of Human liver tissue using anti-ANGPT1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).
Select
Mouse Monoclonal [clone OTI8H2] (IgG1) to Human ANGPT1 / Angiopoietin-1
Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $345.00
ANGPT1 / Angiopoietin-1 Antibody - Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-ANGPT1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min,
Select
Mouse Monoclonal [clone OTI8H2] (IgG1) to Human ANGPT1 / Angiopoietin-1
Human
IHC, WB
Unconjugated, Carrier-free
100µg   $395.00
ANGPT1 / Angiopoietin-1 Antibody - Immunohistochemistry of paraffin-embedded rat lung tissue.
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Mouse, Rat, Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $255.00; 100µl   $315.00; 200µl   $425.00
Select
Rabbit Polyclonal (IgG) to Human ANGPT1 / Angiopoietin-1
Human
ELISA, IHC, WB
HRP Conjugated, Liquid
25µl   1mg/ml   $235.00

Viewing 1-25 of 137 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).