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Angiotensin II

Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE), primarily through ACE within the lung (but also present in endothelial cells and kidney epithelial cells). ACE found in other tissues of the body has no physiological role (ACE has a high density in the lung, but activation here promotes no vasoconstriction, angiotensin II is below physiological levels of action). Angiotensin II acts as an endocrine, autocrine/paracrine, and intracrine hormone. Angiotensin II is degraded to angiotensin III by angiotensinases located in red blood cells and the vascular beds of most tissues. It has a half-life in circulation of around 30 seconds, whereas, in tissue, it may be as long as 15–30 minutes.

Angiotensin II Target Details

Target Name: Angiotensin II

Publications (2)

1
The Mechanism of High-Output Cardiac Hypertrophy Arising From Potassium Channel Gain-of-Function in Cantú Syndrome. Conor McClenaghan, Yan Huang, Scot J Matkovich, Attila Kovacs, Carla J Weinheimer, Ron Perez, Thomas J Broekelmann, Theresa M Harter, Jin-Moo Lee, Maria S Remedi, Colin G Nichols. Funtion (Oxford, England). 2020 September;1:zqaa004. [Full Text Article] [PubMed:32865539] [PMC:PMC7446247]
2
The Role of SGLT2 Inhibitor Ipragliflozin on Cardiac Hypertrophy and microRNA Expression Profiles in a Non-diabetic Rat Model of Cardiomyopathy. Toshiyuki Takasu. Biological & pharmaceutical bulletin. 2022 September;45:1321-1331. [Full Text Article] [PubMed:36047201]

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Angiotensin II Rabbit anti-Human Polyclonal (aa25-32) Antibody
Human
ICC, IF, IHC, IHC-Fr, IHC-P
Unconjugated
50 µl/$732
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Angiotensin II Mouse anti-Human Monoclonal Antibody
Human
ELISA
Unconjugated
100 µg/$860
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Angiotensin II Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µg/$832
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Angiotensin II Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA
Unconjugated
20 µg/$242; 100 µg/$304; 200 µg/$334; 500 µg/$452
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Angiotensin II Rabbit anti-Human Polyclonal (Preservative Free) (Biotin) Antibody
Human
ELISA
Biotin Conjugated, Preservative Free
50 µg/$343
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Angiotensin II Rabbit anti-Human Polyclonal (HRP) Antibody
Mouse, Rat, Human
ELISA
HRP Conjugated
100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439
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Angiotensin II Rabbit anti-Human Polyclonal (Biotin) Antibody
Mouse, Rat, Human
ICC, IP, WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
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Angiotensin II Rabbit anti-Human Polyclonal (FITC) Antibody
Mouse, Rat, Human
ICC, IP, WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549
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Angiotensin II Rabbit anti-Human Polyclonal (APC, Cy7) Antibody
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ICC, IP, WB
APC, Cy7 Conjugated
100 µl/$476; 200 µl/$590; 500 µl/$1,069; 1 ml/$1,265; 2 ml/$1,771; 5 ml/$3,319
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Angiotensin II Rabbit anti-Human Polyclonal (APC) Antibody
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APC Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
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Angiotensin II Rabbit anti-Human Polyclonal (PE) Antibody
Mouse, Rat, Human
ICC, IP, WB
PE Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
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Angiotensin II Rabbit anti-Human Polyclonal (Cy3) Antibody
Mouse, Rat, Human
ICC, IP, WB
Cy3 Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
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Angiotensin II Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
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Angiotensin II Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ICC, IP, WB
HRP Conjugated
100 µl/$325; 200 µl/$375; 500 µl/$539; 1 ml/$632; 2 ml/$867; 5 ml/$1,439
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Angiotensin II Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ICC, IP, WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
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Angiotensin II Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ICC, IP, WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549
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Angiotensin II Rabbit anti-Human Polyclonal (APC, Cy7) Antibody
Human
ICC, IP, WB
APC, Cy7 Conjugated
100 µl/$476; 200 µl/$590; 500 µl/$1,069; 1 ml/$1,265; 2 ml/$1,771; 5 ml/$3,319
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Angiotensin II Rabbit anti-Human Polyclonal (APC) Antibody
Human
ICC, IP, WB
APC Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
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Angiotensin II Rabbit anti-Human Polyclonal (PE) Antibody
Human
ICC, IP, WB
PE Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
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Angiotensin II Rabbit anti-Human Polyclonal (Cy3) Antibody
Human
ICC, IP, WB
Cy3 Conjugated
100 µl/$387; 200 µl/$463; 500 µl/$778; 1 ml/$933; 2 ml/$1,194; 5 ml/$2,213
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).