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Locations
Orders Processing,
Shipping & Receiving,
Warehouse
2 Shaker Rd Suites
B001/B101
Shirley, MA 01464
Production Lab
Floor 6, Suite 620
20700 44th Avenue W
Lynnwood, WA 98036
Telephone Numbers
Tel: +1 (206) 374-1102
Fax: +1 (206) 577-4565
Contact Us
Additional Contact Details
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Angiotensin I
Angiotensin I (Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu | Val-Ile-...) is formed by the action of renin on angiotensinogen. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide (des-Asp) angiotensin I. Renin is produced in the kidneys in response to renal sympathetic activity, decreased intrarenal blood pressure (<90mmHg systolic blood pressure) at the juxtaglomerular cells, or decreased delivery of Na+ and Cl- to the macula densa. If less Na+ is sensed by the macula densa, renin release by juxtaglomerular cells is increased. Angiotensin I appears to have no biological activity and exists solely as a precursor to angiotensin II.
Angiotensin I Target Details
| Target Name: | Angiotensin I |
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