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AMTN

amelotin

The mineralized portions of teeth, the dentin and enamel, are formed by mesenchyme-derived odontoblasts and epithelium-derived ameloblasts, respectively. As ameloblasts differentiate, they deposit specific proteins necessary for enamel formation, including amelogenin (AMELX; MIM 300391), enamelin (ENAM; MIM 606585), and ameloblastin (AMBN; MIM 601259), in the organic enamel matrix. Amelotin is specifically expressed in maturation-stage ameloblasts (Iwasaki et al., 2005 [PubMed 16304441]).

Gene Name:	amelotin
Synonyms:	AMTN, Amelotin, RSTI689, UNQ689
Target Sequences:	NM_212557 NP_997722.1 Q6UX39

Publications (1)

Amelotin is expressed in retinal pigment epithelium and localizes to hydroxyapatite deposits in dry age-related macular degeneration. Dinusha Rajapakse, Katherine Peterson, Sanghamitra Mishra, Jianguo Fan, Joshua Lerner, Maria Campos, Graeme Wistow. Translational research : the journal of laboratory and clinical medicine. 2020 May;219:45-62. [Full Text Article] [PubMed:32160961] [PMC:PMC7197213] Related Antibodies: LS-C799006, LS-C319460.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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