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AMOG / ATP1B2
ATPase, Na+/K+ transporting, beta 2 polypeptide
AMOG / ATP1B2 belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 2 subunit. Two transcript variants encoding different isoforms have been found for this gene.
| Gene Name: | ATPase, Na+/K+ transporting, beta 2 polypeptide |
| Family/Subfamily: | Transporter , ATPase - P type, beta subunit |
| Synonyms: | ATP1B2, Adhesion molecule on glia, AMOG |
| Target Sequences: | NM_001678 NP_001669.3 P14415 |
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