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AML1 / RUNX1

runt-related transcription factor 1

CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation.

Gene Name: runt-related transcription factor 1
Synonyms: RUNX1, AMLCR1, Aml1 oncogene, AML1, AML1-EVI-1, CBF-alpha-2, CBFA2, Acute myeloid leukemia 1, EVI-1, PEBP2A2, PEA2-alpha B, AML1-EVI-1 fusion protein, Oncogene AML-1, PEBP2-alpha B, PEBP2aB
Target Sequences: NM_001754 NP_001745.2 Q01196

Publications (7)

1
TNF-a signaling regulates RUNX1 function in endothelial cells. Hannah A B Whitmore, Dhanesh Amarnani, Michael O'Hare, Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Julien Pedron, John H Bushweller, Joseph F Arboleda-Velasquez, Leo A Kim. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 November; [Full Text Article] [PubMed:33135824] [PMC:PMC7821222] Related Antibodies: LS-B13948.
2
Topical delivery of a small molecule RUNX1 transcription factor inhibitor for the treatment of proliferative vitreoretinopathy. Santiago Delgado-Tirado, Dhanesh Amarnani, Guannan Zhao, Elizabeth J Rossin, Dean Eliott, John B Miller, Whitney A Greene, Leslie Ramos, Said Arevalo-Alquichire, David Leyton-Cifuentes, Lucia Gonzalez-Buendia, Daniela Isaacs-Bernal, Hannah A B Whitmore, Natalia Chmielewska, Brandon V Duffy, Eric Kim, Heuy-Ching Wang, Jose M Ruiz-Moreno, Leo A Kim, Joseph F Arboleda-Velasquez. Scientific reports. 2020 November;10:20554. [Full Text Article] [PubMed:33257736] [PMC:PMC7705016] Related Antibodies: LS-B13948.
3
Clinicopathological Significance of RUNX1 in Non-Small Cell Lung Cancer. Yujin Kim, Bo Bin Lee, Dongho Kim, Sangwon Um, Eun Yoon Cho, Joungho Han, Young Mog Shim, Duk-Hwan Kim. Journal of Clinical Medicine. 2020 June;9: [Full Text Article] [PubMed:32498288] [PMC:PMC7356912] Related Antibodies: LS-B5382.
4
Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Michael O'Hare, Dhanesh Amarnani, Hannah A B Whitmore, Miranda An, Claudia Marino, Leslie Ramos, Santiago Delgado-Tirado, Xinyao Hu, Natalia Chmielewska, Anita Chandrahas, Antonia Fitzek, Fabian Heinrich, Stefan Steurer, Benjamin Ondruschka, Markus Glatzel, Susanne Krasemann, Diego Sepulveda-Falla, David Lagares, Julien Pedron, John H Bushweller, Paul Liu, Joseph F Arboleda-Velasquez, Leo A Kim. The American journal of pathology. 2021 Jul;;191:1193-1208. [Full Text Article] [PubMed:33894177] [PMC:PMC8059259] Related Antibodies: LS-B13948.
5
Runt related transcription factor-1 plays a central role in vessel co-option of colorectal cancer liver metastases. Miran Rada, Audrey Kapelanski-Lamoureux, Stephanie Petrillo, Sébastien Tabariès, Peter Siegel, Andrew R Reynolds, Anthoula Lazaris, Peter Metrakos. Communications biology. 2021 Aug;4:950. [Full Text Article] [PubMed:34376784] [PMC:PMC8355374] Related Antibodies: LS-C353932.
6
Topical Nanoemulsion of a Runt-related Transcription Factor 1 Inhibitor for the Treatment of Pathologic Ocular Angiogenesis. Santiago Delgado-Tirado, Lucia Gonzalez-Buendia, Miranda An, Dhanesh Amarnani, Daniela Isaacs-Bernal, Hannah Whitmore, Said Arevalo-Alquichire, David Leyton-Cifuentes, Jose M Ruiz-Moreno, Joseph F Arboleda-Velasquez, Leo A Kim. Ophthalmology science. 2022 September;2: [Full Text Article] [PubMed:36213726] [PMC:PMC9536424] Related Antibodies: LS-B13948.
7
The molecular mechanisms underlying neutrophil infiltration in vessel co-opting colorectal cancer liver metastases. Miran Rada, Nour Hassan, Anthoula Lazaris, Peter Metrakos. Frontiers in oncology. 2022 November;12:1004793. [Full Text Article] [PubMed:36330498] [PMC:PMC9623070] Related Antibodies: LS-C353932.
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ELISA Kits (8)
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AML1 / RUNX1 (8)
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Nuclear Lysates (2)
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AML1 / RUNX1 ELISA Kit
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Mouse/Human/Rat Phospho-AML1 / RUNX1 (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F844
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$849
AML1 / RUNX1 ELISA Kit
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Rat AML1 / RUNX1 (Sandwich ELISA) ELISA Kit - LS-F65820
Sandwich
96-Well Strip Plate
Rat
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
AML1 / RUNX1 ELISA Kit
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Mouse AML1 / RUNX1 (Sandwich ELISA) ELISA Kit - LS-F65316
Sandwich
96-Well Strip Plate
Mouse
7.8 - 500 pg/ml
1 Plate/$783
AML1 / RUNX1 ELISA Kit
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Mouse/Human Phospho-AML1 / RUNX1 (DNA-Binding Phosphorylation ELISA) ELISA Kit - LS-F845
DNA Binding Phosphorylation
12 x 8-Well Microstrips
Mouse, Human
Colorimetric - 450nm (TMB)
Cell Lysates, Nuclear Lysates
1 Plate/$735
AML1 / RUNX1 ELISA Kit
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Mouse/Human/Rat Phospho-AML1 / RUNX1 (Ser276) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1116
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
AML1 / RUNX1 ELISA Kit
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Mouse/Human/Rat Phospho-AML1 / RUNX1 (Ser303) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1117
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
AML1 / RUNX1 ELISA Kit
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Mouse/Human/Rat Phospho-AML1 / RUNX1 (Ser435) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1722
Cell-Based Phosphorylation
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$668
AML1 / RUNX1 ELISA Kit
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Mouse/Human/Rat AML1 / RUNX1 (Cell-Based ELISA) ELISA Kit - LS-F1792
Cell-Based
96-Well Microplate
Mouse, Human, Rat
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
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