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AMIGO2

adhesion molecule with Ig-like domain 2

AMIGO2/ALIVIN-1 is a member of a small family of type I membrane proteins containing six leucine rich repeats (LRR), one immunoglobulin domain and cysteine rich LLR -NH2 and -COOH domains. In assays a substrate bound form of AMIGO2 promoted prominent neurite extension and inhibited fasciculation of neurites. A homophilic and heterophilic binding mechanism exists between members of the AMIGO family. AMIGOs are thought to be novel cell adhesion molecules expressed on fiber tracts of neuronal tissues that participate in their formation.

Gene Name: adhesion molecule with Ig-like domain 2
Synonyms: AMIGO2, ALI1, Alivin 1, Alivin-1, Alvin 1, AMIGO-2, Amphoterin induced gene 2, Amphoterin-induced protein 2, Transmembrane protein AMIGO2, DEGA
Target Sequences: NM_181847 NP_862830.1 Q86SJ2

Publications (2)

1
Altered Gene Expression Profiles in the Lungs of Streptozotocin-induced Diabetic Mice. Jung-Hyun Kim, Roya Rasaei, Sujin Park, Ji-Young Kim, Sunghun Na, Seok-Ho Hong. Development & reproduction. 2020 September;24:197-205. [Full Text Article] [PubMed:33110951] [PMC:PMC7576965] Related Antibodies: LS-C404504.
2
Establishment of an antibody specific for AMIGO2 improves immunohistochemical evaluation of liver metastases and clinical outcomes in patients with colorectal cancer. Keisuke Goto, Mitsuhiko Osaki, Runa Izutsu, Hiroshi Tanaka, Ryo Sasaki, Akimitsu Tanio, Hiroyuki Satofuka, Yasuhiro Kazuki, Manabu Yamamoto, Hiroyuki Kugoh, Hisao Ito, Mitsuo Oshimura, Yoshiyuki Fujiwara, Futoshi Okada. Diagnostic pathology. 2022 January;17:16. [Full Text Article] [PubMed:35094710] [PMC:PMC8802484] Related Antibodies: LS-C404504.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).