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Alpha SNAP

N-ethylmaleimide-sensitive factor attachment protein, alpha

The 'SNARE hypothesis' is a model explaining the process of docking and fusion of vesicles to their target membranes. According to this model, membrane proteins from the vesicle (v-SNAREs) and proteins from the target membrane (t-SNAREs) govern the specificity of vesicle targeting and docking through mutual recognition. Once the 2 classes of SNAREs bind to each other, they form a complex that recruits the general elements of the fusion apparatus, namely NSF (N-ethylmaleimide-sensitive factor) and SNAPs (soluble NSF-attachment proteins), to the site of membrane fusion, thereby forming the 20S fusion complex. Alpha- and gamma-SNAP are found in a wide range of tissues and act synergistically in intra-Golgi transport. The sequence of the predicted 295-amino acid human protein encoded by NAPA shares 37%, 60%, and 67% identity with the sequences of yeast, Drosophila, and squid alpha-SNAP, respectively. Platelets contain some of the same proteins, including NSF, p115/TAP, alpha-SNAP, gamma-SNAP, and the t-SNAREs syntaxin-2 and syntaxin-4, that are used in many vesicular transport processes in other cell types. Platelet exocytosis uses a molecular mechanism similar to that used by other secretory cells, such as neurons, although the proteins used by the platelet and their modes of regulation may be quite different.

Gene Name: N-ethylmaleimide-sensitive factor attachment protein, alpha
Synonyms: NAPA, Alpha SNAP, Alpha-SNAP, SNAP-alpha, SNAPA
Target Sequences: NM_003827 NP_003818.2 P54920

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Products
Antibodies (27)
Primary (27)
Alpha SNAP (27)
Human (24)
Mouse (8)
Rat (10)
Bovine (5)
Chimpanzee (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (1)
Pig (3)
Rabbit (3)
Zebrafish (3)
IHC (8)
IHC-P (2)
WB (24)
ELISA (11)
ICC (2)
IF (1)
IP (3)
rabbit (25)
mouse (2)
Product Group
IHCPlus (1)
IgG (15)
IgG1 (2)
monoclonal mc (2)
polyclonal pc (25)
15D4 (1)
AP Conjugated (1)
APC (1)
APC Conjugated (1)
Biotin Conjugated (3)
Cy3 Conjugated (1)
Cy7 Conjugated (1)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Preservative Free (1)
Unconjugated (13)
aa1-295 (8)
N-Terminus (4)
aa78-295 (1)
No (27)
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Alpha SNAP Mouse anti-Human Monoclonal (15D4) Antibody
Bovine, Rat
ELISA, IP, WB
Unconjugated
100 µg/$466
Alpha SNAP Antibody - Anti-Alpha SNAP antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 7.5 ug/ml.
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Alpha SNAP Rabbit anti-Human Polyclonal (aa78-295) Antibody
Mouse, Rat, Human, Monkey
ICC, IHC, IHC-P, WB
Unconjugated
50 µl/$460
Alpha SNAP Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using antibody at dilution of 1:100.
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Alpha SNAP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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Alpha SNAP Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated
50 µg/$294; 100 µg/$360
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Alpha SNAP Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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Alpha SNAP Rabbit anti-Human Polyclonal (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
50 µg/$294; 100 µg/$360
Alpha SNAP Antibody - Anti-NAPA rabbit polyclonal antibody at 1:500 dilution. Lane A: Jurkat Whole Cell Lysate. Lysates/proteins at 30 ug per lane. Secondary: Goat Anti-Rabbit IgG H&L (Dylight 800) at 1/10000 dilution. Developed using the Odyssey technique. Performed under reducing conditions. Predicted band size: 33 kDa. Observed band size: 36 kDa. (We are unsure as to the identity of these extra bands.)
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Alpha SNAP Rabbit anti-Human Polyclonal (Preservative Free) Antibody
Human
ELISA, ICC, IF, IP, WB
Unconjugated, Preservative Free
100 µl/$412
Alpha SNAP Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using NAPA Polyclonal Antibody at dilution of 1:35.
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Alpha SNAP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Alpha SNAP Antibody - Immunohistochemistry of paraffin-embedded mouse brain tissue.
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Alpha SNAP Rabbit anti-Human Polyclonal (AP) Antibody
Mouse, Rat, Human
IHC, WB
AP Conjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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Alpha SNAP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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Alpha SNAP Mouse anti-Bovine Monoclonal Antibody
Bovine, Rat
ELISA, IP, WB
Unconjugated
100 µg/$419
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Alpha SNAP Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µl/$412
Select
Alpha SNAP Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µg/$331
Select
Alpha SNAP Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
100 µg/$331
Select
Alpha SNAP Rabbit anti-Human Polyclonal (N-Terminus) Antibody
WB
Unconjugated
100 µl/$397
Select
Alpha SNAP Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Gibbon, Chimpanzee
WB
HRP Conjugated
100 µl/$442
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Alpha SNAP Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Gibbon, Chimpanzee
WB
Biotin Conjugated
100 µl/$442
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Alpha SNAP Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Zebrafish, Pig, Horse, Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Human, Gibbon, Chimpanzee
WB
FITC Conjugated
100 µl/$442
Alpha SNAP Antibody - Western blot analysis of SNAP-alpha expression in HeLa (A); Jurkat (B); mouse brain (C); mouse lung (D); rat liver (E) whole cell lysates.
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Alpha SNAP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
Alpha SNAP Antibody - Western blot of Alpha SNAP antibody.
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Alpha SNAP Rabbit anti-Human Polyclonal (aa1-295) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561
Alpha SNAP Antibody - Western blot of Alpha SNAP antibody.
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Alpha SNAP Rabbit anti-Human Polyclonal (aa1-295) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$338; 200 µl/$393; 500 µl/$575; 1 ml/$702
Alpha SNAP Antibody - Western blot of Alpha SNAP antibody.
Select
Alpha SNAP Rabbit anti-Human Polyclonal (aa1-295) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$319; 200 µl/$365; 500 µl/$519; 1 ml/$596
Alpha SNAP Antibody - Western blot of Alpha SNAP antibody.
Select
Alpha SNAP Rabbit anti-Human Polyclonal (aa1-295) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$348; 200 µl/$407; 500 µl/$605; 1 ml/$755
Alpha SNAP Antibody - Western blot of Alpha SNAP antibody.
Select
Alpha SNAP Rabbit anti-Human Polyclonal (aa1-295) (PE) Antibody
Human
WB
PE Conjugated
100 µl/$407; 200 µl/$491; 500 µl/$850; 1 ml/$1,008
Alpha SNAP Antibody - Western blot of Alpha SNAP antibody.
Select
Alpha SNAP Rabbit anti-Human Polyclonal (aa1-295) (APC, Cy7) Antibody
Human
WB
APC, Cy7 Conjugated
100 µl/$505; 200 µl/$648; 500 µl/$1,152; 1 ml/$1,401
Viewing 1-25 of 27 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).