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Alpha-1-Antichymotrypsin

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3

Alpha-1-Antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease.

Gene Name: serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
Synonyms: SERPINA3, Alpha-1-antichymotrypsin, AACT, GIG25, Growth-inhibiting protein 25, GIG24, Serpin A3, Growth-inhibiting protein 24, a-1-ACT
Target Sequences: NM_001085 NP_001076.2 P01011

Publications (1)

1
Search for novel STAT3-dependent genes reveals SERPINA3 as a new STAT3 target that regulates invasion of human melanoma cells. Dorota W Kulesza, Kavita Ramji, Marta Maleszewska, Jakub Mieczkowski, Michal Dabrowski, Salem Chouaib, Bozena Kaminska. Laboratory investigation; a journal of technical methods and pathology. 2019 November;99:1607-1621. [Full Text Article] [PubMed:31278347] Related Antibodies: LS-B5826.

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Products
Proteins (11)
Over-Expression Lysate (2)
Recombinant (9)
Alpha-1-Antichymotrypsin (11)
No (11)
6His, C-terminus (2)
6His, N-terminus (1)
GST (2)
His (2)
His-GST (1)
His-T7 (1)
Myc-DDK (Flag) (2)
Human (9)
Mouse (1)
293T Cells (1)
E. coli (4)
HEK 293 Cells (1)
Human Cells (2)
Mammalian Cells (1)
Wheat Germ Extract (2)
Purified (4)
Low endotoxin level (3)
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.3 kDa
10 µg/$317; 50 µg/$524
Alpha-1-Antichymotrypsin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
47.65 kDa
100 µg/$494
Alpha-1-Antichymotrypsin Protein - 12.5% SDS-PAGE of human SERPINA3 stained with Coomassie Blue
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Wheat Germ Extract
GST
69.63 kDa
10 µg/$479; 25 µg/$670
Alpha-1-Antichymotrypsin Protein - 12.5% SDS-PAGE of human SERPINA3 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
72.27 kDa
10 µg/$479; 25 µg/$670
Alpha-1-Antichymotrypsin Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
47.65 kDa
20 µg/$150
Select
Human Cells
His
Less than 1.0 EU/µg protein (determined by LAL method).
46.5 kDa
100 µg/$997; 1 mg/$5,281
Alpha-1-Antichymotrypsin Protein
Select
E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
Alpha-1-Antichymotrypsin Protein
Select
E. coli
6His, N-terminus
47 kDa
10 µg/$265; 50 µg/$315; 100 µg/$365
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.33kD
10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,157
Alpha-1-Antichymotrypsin Protein - Recombinant Alpha-1-Antichymotrypsin By SDS-PAGE
Select
E. coli
His-T7
29.8 kDa
10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
Alpha-1-Antichymotrypsin Protein
Select
E. coli
His-GST
45.1 kDa
10 µg/$252; 50 µg/$315; 100 µg/$417; 200 µg/$522; 1 mg/$1,404; 500 µg/$1,034; 5 mg/$2,303; 2 mg/$1,565
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).