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ALOX12B

Arachidonate 12-lipoxygenase, 12R Type

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.

Gene Name: Arachidonate 12-lipoxygenase, 12R Type
Family/Subfamily: Lipoxygenase
Synonyms: ALOX12B, 12R-LOX, 12R-lipoxygenase, Epidermis-type lipoxygenase 12
Target Sequences: NM_001139 NP_001130.1 O75342

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Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
ALOX12B (6)
No (6)
GST (1)
GST, N-terminus (1)
His-T7, N-terminus (1)
Myc-DDK (Flag) (2)
Human (4)
Mouse (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (3)
ALOX12B Protein - Recombinant Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) by SDS-PAGE
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E. coli
His-T7, N-terminus
29.6kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
ALOX12B Protein - Recombinant Arachidonate-12-Lipoxygenase, 12R Type (ALOX12B) by SDS-PAGE
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E. coli
None
39.7kDa
10 µg/$270; 50 µg/$372; 200 µg/$742; 100 µg/$592; 1 mg/$1,786; 500 µg/$1,352; 5 mg/$2,742; 2 mg/$1,966
ALOX12B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
80.2 kDa
20 µg/$150
ALOX12B Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
80.2 kDa
100 µg/$494
ALOX12B Protein - 12.5% SDS-PAGE of human ALOX12B stained with Coomassie Blue
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Wheat Germ Extract
GST
106.8 kDa
10 µg/$479; 25 µg/$670
ALOX12B Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
2 µg/$439
Viewing 1-6 of 6 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).