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ALK3 / BMPR1A
bone morphogenetic protein receptor, type IA
The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
| Gene Name: | bone morphogenetic protein receptor, type IA |
| Family/Subfamily: | Protein Kinase , Activin/TGFb |
| Synonyms: | BMPR1A, 10q23del, ALK3, ALK-3, BMP type-1A receptor, BMPR-1A, CD292, CD292 antigen, Activin receptor-like kinase 3, ACVRLK3, SKR5 |
| Target Sequences: | NM_004329 NP_004320.2 P36894 |
Publications (5)
1
Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes. Pache G, Schfer C, Wiesemann S, Springer E, Liebau M, Reinhardt HC, August C, Pavenstdt H, Bek MJ. American journal of physiology. Renal physiology. 2006 291:F654-62.
[PubMed:16622178]
2
Binding of carbon nanotube to BMP receptor 2 enhances cell differentiation and inhibits apoptosis via regulating bHLH transcription factors. Zhang Y, Mu Q, Zhou H, Vrijens K, Roussel MF, Jiang G, Yan B. Cell death & disease. 2012 3:e308.
[PubMed:22573038]
[PMC:PMC3366082]
3
A crucial role of bone morphogenetic protein signaling in the wound healing response in acute liver injury induced by carbon tetrachloride. Oumi N, Taniguchi KA, Kanai AM, Yasunaga M, Nakanishi T, Sato K. International journal of hepatology. 2012 2012:476820.
[PubMed:22701178]
[PMC:PMC3372049]
Related Antibodies: LS-C97653.
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ALK3 / BMPR1A Mouse anti-Human Monoclonal (aa179-378) (4B7B2) Antibody
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$459
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa166-195) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa166-195) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa166-195) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa166-195) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
ALK3 / BMPR1A Mouse anti-Human Monoclonal (aa179-378) (4B7B2) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa170-197) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
200 µl/$460
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa30-60) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa166-195) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393; 200 µl/$393
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (Internal) Antibody
Human
IP, WB
Unconjugated
100 µg/$786
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa21-51) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
Flo, WB
Unconjugated
400 µl/$393
ALK3 / BMPR1A Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
ALK3 / BMPR1A Mouse anti-Human Monoclonal (Amino Acid: 179-378) (4B7B2) Antibody
Mouse, Human
Flo, IHC, WB
Unconjugated
100 µg/$503
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa177-532) Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$294; 100 µg/$360
ALK3 / BMPR1A Rabbit anti-Mouse Polyclonal Antibody
Mouse
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa21-51) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa21-51) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa21-51) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa30-60) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa1-30) Antibody
Mouse, Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa1-30) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa1-30) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
ALK3 / BMPR1A Rabbit anti-Human Polyclonal (aa1-30) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
ALK3 / BMPR1A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
100 µl/$412
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